Prenatal alcohol exposure and facial morphology in a UK cohort

Laurence J. Howe; Gemma C. Sharp; Gibran Hemani; Luisa Zuccolo; Stephen Richmond; Sarah J. Lewis

doi:10.1016/j.drugalcdep.2018.11.031

Prenatal alcohol exposure and facial morphology in a UK cohort

Laurence J. Howe, Gemma C. Sharp, Gibran Hemani, Luisa Zuccolo, Stephen Richmond, Sarah J. Lewis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

13 Citations (Scopus)

180 Downloads (Pure)

Abstract

BACKGROUND:
High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.

METHODS:
In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption.

RESULTS:
In both self-reported alcohol consumption (N = 4233) and rs1229984 genotype (N = 3139) analyses, we found no strong statistical evidence for an association between maternal alcohol consumption and facial phenotypes tested. The directions of effect estimates were compatible with the known effects of heavy alcohol exposure, but confidence intervals were largely centered around zero.

CONCLUSIONS:
There is no strong evidence, in a sample representative of the general population, for an effect of prenatal alcohol exposure on normal-range variation in facial morphology.

Original language	English
Pages (from-to)	42-47
Number of pages	6
Journal	Drug and Alcohol Dependence
Volume	197
Early online date	5 Feb 2019
DOIs	https://doi.org/10.1016/j.drugalcdep.2018.11.031
Publication status	Published - 1 Apr 2019

Keywords

Alcohol
ALSPAC
Facial morphology
Mendelian randomization

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This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.drugalcdep.2018.11.031 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 399 KBLicence: CC BY-NC-ND

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title = "Prenatal alcohol exposure and facial morphology in a UK cohort",

abstract = "BACKGROUND:High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.METHODS:In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption.RESULTS:In both self-reported alcohol consumption (N = 4233) and rs1229984 genotype (N = 3139) analyses, we found no strong statistical evidence for an association between maternal alcohol consumption and facial phenotypes tested. The directions of effect estimates were compatible with the known effects of heavy alcohol exposure, but confidence intervals were largely centered around zero.CONCLUSIONS:There is no strong evidence, in a sample representative of the general population, for an effect of prenatal alcohol exposure on normal-range variation in facial morphology.",

keywords = "Alcohol, ALSPAC, Facial morphology, Mendelian randomization",

author = "Howe, {Laurence J.} and Sharp, {Gemma C.} and Gibran Hemani and Luisa Zuccolo and Stephen Richmond and Lewis, {Sarah J.}",

year = "2019",

month = apr,

day = "1",

doi = "10.1016/j.drugalcdep.2018.11.031",

language = "English",

volume = "197",

pages = "42--47",

journal = "Drug and Alcohol Dependence",

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T1 - Prenatal alcohol exposure and facial morphology in a UK cohort

AU - Howe, Laurence J.

AU - Sharp, Gemma C.

AU - Hemani, Gibran

AU - Zuccolo, Luisa

AU - Richmond, Stephen

AU - Lewis, Sarah J.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - BACKGROUND:High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.METHODS:In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption.RESULTS:In both self-reported alcohol consumption (N = 4233) and rs1229984 genotype (N = 3139) analyses, we found no strong statistical evidence for an association between maternal alcohol consumption and facial phenotypes tested. The directions of effect estimates were compatible with the known effects of heavy alcohol exposure, but confidence intervals were largely centered around zero.CONCLUSIONS:There is no strong evidence, in a sample representative of the general population, for an effect of prenatal alcohol exposure on normal-range variation in facial morphology.

AB - BACKGROUND:High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.METHODS:In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption.RESULTS:In both self-reported alcohol consumption (N = 4233) and rs1229984 genotype (N = 3139) analyses, we found no strong statistical evidence for an association between maternal alcohol consumption and facial phenotypes tested. The directions of effect estimates were compatible with the known effects of heavy alcohol exposure, but confidence intervals were largely centered around zero.CONCLUSIONS:There is no strong evidence, in a sample representative of the general population, for an effect of prenatal alcohol exposure on normal-range variation in facial morphology.

KW - Alcohol

KW - ALSPAC

KW - Facial morphology

KW - Mendelian randomization

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U2 - 10.1016/j.drugalcdep.2018.11.031

DO - 10.1016/j.drugalcdep.2018.11.031

M3 - Article (Academic Journal)

C2 - 30772781

AN - SCOPUS:85061435571

SN - 0376-8716

VL - 197

SP - 42

EP - 47

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

ER -

Prenatal alcohol exposure and facial morphology in a UK cohort

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Keywords

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