Prenatal concentrations of Perfluoroalkyl substances and early communication development in British girls

Zuha Jeddy, Terryl J. Hartman, Ethel V. Taylor, Cayla Poteete, Katarzyna Kordas

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Abstract

Abstract Perfluoroalkyl substances (PFAS), found in many household products and classed as endocrine disrupting chemicals, can be transferred through the placenta and are associated with multiple developmental deficits in offspring. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we investigated the association between intrauterine exposure to PFAS and early communication development in 432 mother-daughter dyads at 15 and 38 months of age. Concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) were measured in maternal serum collected during pregnancy. Early communication development was measured with the ALSPAC-adapted MacArthur Communicative Development Inventories for Infants and Toddlers. The infant questionnaire measured verbal comprehension, vocabulary comprehension and production, nonverbal communication, and social development. The toddler questionnaire measured language, intelligibility, and communicative sub-scores. Multivariable linear regression was used to examine associations between each PFAS exposure and each communication sub-scale score. The association between maternal PFAS concentrations and early communication development at 15 and 38 months of age varied by maternal age at delivery. In daughters of younger mothers (< 25 years of age), every 1 ng/mL of PFOS was associated with a 3.82 point (95% confidence interval (CI): − 6.18, − 1.47) lower vocabulary score at 15 months and a 0.80 point (95% CI: − 1.74, 0.14) lower language score at 38 months. Prenatal exposure to select PFAS was positively and negatively associated with communication development among girls, with inconsistent pattern of association across all measured PFAS and endpoints.
Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalEarly Human Development
Volume109
Early online date12 Apr 2017
DOIs
Publication statusPublished - Jun 2017

Keywords

  • PFAS
  • Language
  • Communication skills
  • Child
  • Girls
  • ALSPAC

Fingerprint Dive into the research topics of 'Prenatal concentrations of Perfluoroalkyl substances and early communication development in British girls'. Together they form a unique fingerprint.

Cite this