Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems

Jolien Rijlaarsdam; Charlotte A M Cecil; Esther Walton; Maurissa S C Mesirow; Caroline L Relton; Tom R Gaunt; Wendy McArdle; Edward D Barker

doi:10.1111/jcpp.12589

Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems

Jolien Rijlaarsdam, Charlotte A M Cecil, Esther Walton, Maurissa S C Mesirow, Caroline L Relton, Tom R Gaunt, Wendy McArdle, Edward D Barker

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

BACKGROUND: Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to 'unhealthy diet'. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth.

METHODS: Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7-13) differed for EOP versus low CP youth.

RESULTS: Prenatal 'unhealthy diet' was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal 'unhealthy diet' was associated with higher ADHD symptoms indirectly via higher IGF2 methylation.

CONCLUSIONS: Preventing 'unhealthy diet' in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation.

Original language	English
Pages (from-to)	19-27
Number of pages	9
Journal	Journal of Child Psychology and Psychiatry
Volume	58
Issue number	1
Early online date	18 Aug 2016
DOIs	https://doi.org/10.1111/jcpp.12589
Publication status	Published - Jan 2017

Keywords

DNA methylation
Avon Longitudinal Study of Parents and Children
diet
conduct problems
attention deficit hyperactivity disorder
IGF2

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This is the final published version of the article (version of record). It first appeared online via Wiley at http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12589/abstract. Please refer to any applicable terms of use of the publisher.
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MRC UoB UNITE Unit - Programme 2
Relton, C. L. (Principal Investigator) & Relton, C. L. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
Accessible resource for integrated epigenomics studies (ARIES)
Ring, S. M. (Principal Investigator)
1/01/12 → 1/07/15
Project: Research

Illumina Array
Ring, S. M. (Manager)
Bristol Population Health Science Institute
Facility/equipment: Facility

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Rijlaarsdam, J., Cecil, C. A. M., Walton, E., Mesirow, M. S. C., Relton, C. L., Gaunt, T. R., McArdle, W., & Barker, E. D. (2017). Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems. Journal of Child Psychology and Psychiatry, 58(1), 19-27. https://doi.org/10.1111/jcpp.12589

@article{3275854bf2ba4426a1fa1d90f7b640b0,

title = "Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems",

abstract = "BACKGROUND: Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to 'unhealthy diet'. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth.METHODS: Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7-13) differed for EOP versus low CP youth.RESULTS: Prenatal 'unhealthy diet' was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal 'unhealthy diet' was associated with higher ADHD symptoms indirectly via higher IGF2 methylation.CONCLUSIONS: Preventing 'unhealthy diet' in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation.",

keywords = "DNA methylation, Avon Longitudinal Study of Parents and Children, diet, conduct problems, attention deficit hyperactivity disorder, IGF2",

author = "Jolien Rijlaarsdam and Cecil, \{Charlotte A M\} and Esther Walton and Mesirow, \{Maurissa S C\} and Relton, \{Caroline L\} and Gaunt, \{Tom R\} and Wendy McArdle and Barker, \{Edward D\}",

note = "{\textcopyright} 2016 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley \& Sons Ltd on behalf of Association for Child and Adolescent Mental Health.",

year = "2017",

month = jan,

doi = "10.1111/jcpp.12589",

language = "English",

volume = "58",

pages = "19--27",

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Rijlaarsdam, J, Cecil, CAM, Walton, E, Mesirow, MSC, Relton, CL, Gaunt, TR, McArdle, W & Barker, ED 2017, 'Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems', Journal of Child Psychology and Psychiatry, vol. 58, no. 1, pp. 19-27. https://doi.org/10.1111/jcpp.12589

Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems. / Rijlaarsdam, Jolien; Cecil, Charlotte A M; Walton, Esther et al.
In: Journal of Child Psychology and Psychiatry, Vol. 58, No. 1, 01.2017, p. 19-27.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems

AU - Rijlaarsdam, Jolien

AU - Cecil, Charlotte A M

AU - Walton, Esther

AU - Mesirow, Maurissa S C

AU - Relton, Caroline L

AU - Gaunt, Tom R

AU - McArdle, Wendy

AU - Barker, Edward D

PY - 2017/1

Y1 - 2017/1

N2 - BACKGROUND: Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to 'unhealthy diet'. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth.METHODS: Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7-13) differed for EOP versus low CP youth.RESULTS: Prenatal 'unhealthy diet' was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal 'unhealthy diet' was associated with higher ADHD symptoms indirectly via higher IGF2 methylation.CONCLUSIONS: Preventing 'unhealthy diet' in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation.

AB - BACKGROUND: Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to 'unhealthy diet'. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth.METHODS: Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7-13) differed for EOP versus low CP youth.RESULTS: Prenatal 'unhealthy diet' was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal 'unhealthy diet' was associated with higher ADHD symptoms indirectly via higher IGF2 methylation.CONCLUSIONS: Preventing 'unhealthy diet' in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation.

KW - DNA methylation

KW - Avon Longitudinal Study of Parents and Children

KW - diet

KW - conduct problems

KW - attention deficit hyperactivity disorder

KW - IGF2

U2 - 10.1111/jcpp.12589

DO - 10.1111/jcpp.12589

M3 - Article (Academic Journal)

C2 - 27535767

SN - 0021-9630

VL - 58

SP - 19

EP - 27

JO - Journal of Child Psychology and Psychiatry

JF - Journal of Child Psychology and Psychiatry

IS - 1

ER -

Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems

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MRC UoB UNITE Unit - Programme 2

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Illumina Array

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