Preoperative widespread pain sensitization and chronic pain after hip and knee replacement: a cohort analysis

Vikki Wylde, Adrian Sayers, Erik Lenguerrand, Rachael Gooberman-Hill, Mark Pyke, Andrew D Beswick, Paul Dieppe, Ashley W Blom

Research output: Contribution to journalArticle (Academic Journal)peer-review

111 Citations (Scopus)


Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this study was to investigate whether preoperative widespread pain sensitivity was associated with chronic pain after joint replacement. Data were analyzed from 254 patients receiving THR and 239 patients receiving TKR. Pain was assessed preoperatively and at 12 months after surgery using the Western Ontario and McMaster Universities Osteoarthritis Pain Scale. Preoperative widespread pain sensitivity was assessed through measurement of pressure pain thresholds (PPTs) at the forearm using an algometer. Statistical analysis was conducted using linear regression and linear mixed models, and adjustments were made for confounding variables. In both the THR and TKR cohort, lower PPTs (heightened widespread pain sensitivity) were significantly associated with higher preoperative pain severity. Lower PPTs were also significantly associated with higher pain severity at 12 months after surgery in the THR cohort. However, PPTs were not associated with the change in pain severity from preoperative to 12 months postoperative in either the TKR or THR cohort. These findings suggest that although preoperative widespread pressure pain sensitivity is associated with pain severity before and after joint replacement, it is not a predictor of the amount of pain relief that patients gain from joint replacement surgery, independent of preoperative pain severity.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
Issue number1
Publication statusPublished - Jan 2015

Structured keywords

  • Centre for Surgical Research


  • Aged
  • Arthroplasty, Replacement, Hip
  • Arthroplasty, Replacement, Knee
  • Chronic Pain
  • Cohort Studies
  • Cross-Sectional Studies
  • Double-Blind Method
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Pain Measurement
  • Pain, Postoperative
  • Preoperative Care
  • Prospective Studies


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