Prevalence and impact of long-term use of nicotine replacement therapy in UK stop-smoking services: findings from the ELONS study

Lion Shahab, Fiona Dobbie, Rosemary Hiscock, Ann McNeill, Linda Bauld

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

BACKGROUND: Nicotine Replacement Therapy (NRT) was licensed for harm reduction in the UK in 2005, and guidance to UK Stop Smoking Services (SSS) to include long-term partial or complete substitution of cigarettes with NRT was issued in 2013. Yet, NRT prevalence data and data on changes in biomarkers associated with long-term NRT use among SSS clients are scarce.

METHODS: SSS clients abstinent 4 weeks post-quit date were followed up at 12 months. At baseline standard socio-demographic, smoking and SSS use characteristics were collected and of those eligible, 60.6% (1,047/1,728) provided data on smoking status and NRT use at follow-up. A subsample also provided saliva samples at baseline and of those eligible, 36.2% (258/712) provided follow-up samples. Saliva was analysed for cotinine (a metabolite of nicotine) and alpha-amylase (a stress biomarker).

RESULTS: Among those who had used NRT during their initial quit attempt (61.5%, 95%CI 58.4-64.6), 6.0% (95%CI 4.3-8.3%) were still using NRT at one year, significantly more ex-smokers than relapsed smokers (9.5% vs. 3.7%; p=0.005). In adjusted analysis, NRT use interacted with smoking status to determine change in cotinine, but not alpha-amylase, levels (Wald χ(2) (1)=13.0, p<0.001): cotinine levels remained unchanged in relapsed smokers and ex-smokers with long-term NRT use but decreased in ex-smokers without long-term NRT use.

CONCLUSIONS: Long-term NRT use is uncommon in SSS clients, particularly among relapsed smokers. Its use is associated with continued high intake of nicotine among ex-smokers but does not increase nicotine intake in smokers. It does not appear to affect stress response.

IMPLICATIONS: Little is known about the long-term effects of Nicotine Replacement Therapy (NRT). Given an increasing shift towards harm reduction in tobacco control, reducing the harm from combustible products by complete or partial substitution with non-combustible products, more data on long-term use are needed. This study shows that in the context of stop smoking services, clients rarely use products for up to a year and that NRT use does not affect users' stress response. Ex-smokers using NRT long-term can completely replace nicotine from cigarettes with nicotine from NRT; long-term NRT use by continuing smokers does not increase nicotine intake. Long-term NRT appears to be a safe and effective way to reduce exposure to combustible nicotine.

Original languageEnglish
Article numberntw258
Pages (from-to)81-88
Number of pages8
JournalNicotine and Tobacco Research
Volume20
Issue number1
Early online date24 Sep 2016
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Nicotine
  • nicotine replacement therapy
  • Smoking
  • alpha-Amylases
  • Biological markers
  • Cotinine
  • Follow-up
  • Stress
  • Clients

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