Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom

James W Swann; Christina L Maunder; Emma M Roberts; Gerard McLauchlan; Sophie E Adamantos

doi:10.1111/vec.12434

Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom

James W Swann, Christina L Maunder, Emma M Roberts, Gerard McLauchlan, Sophie E Adamantos

Research output: Contribution to journal › Article (Academic Journal) › peer-review

5 Citations (Scopus)

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Abstract

OBJECTIVE: To determine the prevalence of hemorrhagic gastro-intestinal (GI) disease developing in dogs and cats admitted for management of non-GI disease in veterinary intensive care units (ICUs).

DESIGN: Retrospective study of animals presented between October 2012 and July 2013.

SETTING: Three ICUs located in veterinary teaching hospitals in the United Kingdom.

ANIMALS: Dogs (n = 272) and cats (n = 94) were consecutively enrolled from 3 ICUs if they were hospitalized in the unit for at least 24 hours. Cases were excluded if they had hemorrhagic GI disease in the 48-hour period before presentation or in the 24-hour period after admission. Cases were also excluded if they suffered skull fracture, epistaxis, or hemoptysis, if they underwent surgical procedures of the GI or upper respiratory tracts, or if they were presented for management of GI disease.

MEASUREMENTS AND MAIN RESULTS: Hemorrhagic GI disease was observed in dogs at all 3 units, but at different rates (Center 1: 10.3%, Center 2: 4.8%, Center 3: 2.2%). Hemorrhagic GI disease was not observed in cats at any of the participating centers. Construction of a multivariable logistic regression model revealed that serum albumin concentration, administration of prophylactic gastro-protectant drugs, and institution were significantly associated with the development of hemorrhagic GI disease in dogs. Development of hemorrhagic GI disease and placement of a feeding tube were significantly associated with mortality during the period of hospitalization in dogs. Thirty-seven (13.6%) dogs and 12 (12.8%) cats died or were euthanized while hospitalized, with a higher mortality rate (42.1%) in dogs with hemorrhagic GI disease.

CONCLUSIONS: Hemorrhagic GI disease does develop in dogs hospitalized for management of non-GI disease, but this phenomenon was not observed in cats. Development of hemorrhagic GI disease appeared to have a significant impact on survival in veterinary ICUs.

Original language	English
Pages (from-to)	419-427
Number of pages	9
Journal	Journal of Veterinary Emergency and Critical Care
Volume	26
Issue number	3
Early online date	7 Dec 2015
DOIs	https://doi.org/10.1111/vec.12434
Publication status	Published - Jun 2016

Keywords

enteral feeding
omeprazole
stress-related mucosal disease
stress ulcer prophylaxis

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10.1111/vec.12434

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This is the peer reviewed version of the following article: Swann, J. W., Maunder, C. L., Roberts, E., McLauchlan, G. and Adamantos, S. (2015), Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom. Journal of Veterinary Emergency and Critical Care, which has been published in final form at doi: 10.1111/vec.12434. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 113 KBLicence: CC BY-NC

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@article{d3a5828f328e402abcd5bc0ba3d3ef56,

title = "Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom",

abstract = "OBJECTIVE: To determine the prevalence of hemorrhagic gastro-intestinal (GI) disease developing in dogs and cats admitted for management of non-GI disease in veterinary intensive care units (ICUs).DESIGN: Retrospective study of animals presented between October 2012 and July 2013.SETTING: Three ICUs located in veterinary teaching hospitals in the United Kingdom.ANIMALS: Dogs (n = 272) and cats (n = 94) were consecutively enrolled from 3 ICUs if they were hospitalized in the unit for at least 24 hours. Cases were excluded if they had hemorrhagic GI disease in the 48-hour period before presentation or in the 24-hour period after admission. Cases were also excluded if they suffered skull fracture, epistaxis, or hemoptysis, if they underwent surgical procedures of the GI or upper respiratory tracts, or if they were presented for management of GI disease.MEASUREMENTS AND MAIN RESULTS: Hemorrhagic GI disease was observed in dogs at all 3 units, but at different rates (Center 1: 10.3%, Center 2: 4.8%, Center 3: 2.2%). Hemorrhagic GI disease was not observed in cats at any of the participating centers. Construction of a multivariable logistic regression model revealed that serum albumin concentration, administration of prophylactic gastro-protectant drugs, and institution were significantly associated with the development of hemorrhagic GI disease in dogs. Development of hemorrhagic GI disease and placement of a feeding tube were significantly associated with mortality during the period of hospitalization in dogs. Thirty-seven (13.6%) dogs and 12 (12.8%) cats died or were euthanized while hospitalized, with a higher mortality rate (42.1%) in dogs with hemorrhagic GI disease.CONCLUSIONS: Hemorrhagic GI disease does develop in dogs hospitalized for management of non-GI disease, but this phenomenon was not observed in cats. Development of hemorrhagic GI disease appeared to have a significant impact on survival in veterinary ICUs.",

keywords = "enteral feeding, omeprazole, stress-related mucosal disease, stress ulcer prophylaxis",

author = "Swann, {James W} and Maunder, {Christina L} and Roberts, {Emma M} and Gerard McLauchlan and Adamantos, {Sophie E}",

note = "{\textcopyright} Veterinary Emergency and Critical Care Society 2015.",

year = "2016",

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doi = "10.1111/vec.12434",

language = "English",

volume = "26",

pages = "419--427",

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Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom. / Swann, James W; Maunder, Christina L; Roberts, Emma M; McLauchlan, Gerard; Adamantos, Sophie E.

In: Journal of Veterinary Emergency and Critical Care, Vol. 26, No. 3, 06.2016, p. 419-427.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom

AU - Swann, James W

AU - Maunder, Christina L

AU - Roberts, Emma M

AU - McLauchlan, Gerard

AU - Adamantos, Sophie E

PY - 2016/6

Y1 - 2016/6

N2 - OBJECTIVE: To determine the prevalence of hemorrhagic gastro-intestinal (GI) disease developing in dogs and cats admitted for management of non-GI disease in veterinary intensive care units (ICUs).DESIGN: Retrospective study of animals presented between October 2012 and July 2013.SETTING: Three ICUs located in veterinary teaching hospitals in the United Kingdom.ANIMALS: Dogs (n = 272) and cats (n = 94) were consecutively enrolled from 3 ICUs if they were hospitalized in the unit for at least 24 hours. Cases were excluded if they had hemorrhagic GI disease in the 48-hour period before presentation or in the 24-hour period after admission. Cases were also excluded if they suffered skull fracture, epistaxis, or hemoptysis, if they underwent surgical procedures of the GI or upper respiratory tracts, or if they were presented for management of GI disease.MEASUREMENTS AND MAIN RESULTS: Hemorrhagic GI disease was observed in dogs at all 3 units, but at different rates (Center 1: 10.3%, Center 2: 4.8%, Center 3: 2.2%). Hemorrhagic GI disease was not observed in cats at any of the participating centers. Construction of a multivariable logistic regression model revealed that serum albumin concentration, administration of prophylactic gastro-protectant drugs, and institution were significantly associated with the development of hemorrhagic GI disease in dogs. Development of hemorrhagic GI disease and placement of a feeding tube were significantly associated with mortality during the period of hospitalization in dogs. Thirty-seven (13.6%) dogs and 12 (12.8%) cats died or were euthanized while hospitalized, with a higher mortality rate (42.1%) in dogs with hemorrhagic GI disease.CONCLUSIONS: Hemorrhagic GI disease does develop in dogs hospitalized for management of non-GI disease, but this phenomenon was not observed in cats. Development of hemorrhagic GI disease appeared to have a significant impact on survival in veterinary ICUs.

AB - OBJECTIVE: To determine the prevalence of hemorrhagic gastro-intestinal (GI) disease developing in dogs and cats admitted for management of non-GI disease in veterinary intensive care units (ICUs).DESIGN: Retrospective study of animals presented between October 2012 and July 2013.SETTING: Three ICUs located in veterinary teaching hospitals in the United Kingdom.ANIMALS: Dogs (n = 272) and cats (n = 94) were consecutively enrolled from 3 ICUs if they were hospitalized in the unit for at least 24 hours. Cases were excluded if they had hemorrhagic GI disease in the 48-hour period before presentation or in the 24-hour period after admission. Cases were also excluded if they suffered skull fracture, epistaxis, or hemoptysis, if they underwent surgical procedures of the GI or upper respiratory tracts, or if they were presented for management of GI disease.MEASUREMENTS AND MAIN RESULTS: Hemorrhagic GI disease was observed in dogs at all 3 units, but at different rates (Center 1: 10.3%, Center 2: 4.8%, Center 3: 2.2%). Hemorrhagic GI disease was not observed in cats at any of the participating centers. Construction of a multivariable logistic regression model revealed that serum albumin concentration, administration of prophylactic gastro-protectant drugs, and institution were significantly associated with the development of hemorrhagic GI disease in dogs. Development of hemorrhagic GI disease and placement of a feeding tube were significantly associated with mortality during the period of hospitalization in dogs. Thirty-seven (13.6%) dogs and 12 (12.8%) cats died or were euthanized while hospitalized, with a higher mortality rate (42.1%) in dogs with hemorrhagic GI disease.CONCLUSIONS: Hemorrhagic GI disease does develop in dogs hospitalized for management of non-GI disease, but this phenomenon was not observed in cats. Development of hemorrhagic GI disease appeared to have a significant impact on survival in veterinary ICUs.

KW - enteral feeding

KW - omeprazole

KW - stress-related mucosal disease

KW - stress ulcer prophylaxis

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U2 - 10.1111/vec.12434

DO - 10.1111/vec.12434

M3 - Article (Academic Journal)

C2 - 26641416

VL - 26

SP - 419

EP - 427

JO - Journal of Veterinary Emergency and Critical Care

JF - Journal of Veterinary Emergency and Critical Care

SN - 1479-3261

IS - 3

ER -

Prevalence and risk factors for development of hemorrhagic gastro-intestinal disease in veterinary intensive care units in the United Kingdom

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Keywords

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