Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019

David J Roberts; Grahame S Davis; Michelle J Cole; Dixita Naik; Hitiksha Maru; Neil Woodford; Peter Muir; Paddy Horner; Ian Simms; George Thickett; Paul Crook; Kirsty Foster; Nick Andrews; John Saunders; Helen Fifer; Kate Folkard; O Noel Gill; null On Behalf Of The Incident Management Team

doi:10.2807/1560-7917.ES.2019.24.38.1900557

Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019

David J Roberts, Grahame S Davis, Michelle J Cole, Dixita Naik, Hitiksha Maru, Neil Woodford, Peter Muir, Paddy Horner, Ian Simms, George Thickett, Paul Crook, Kirsty Foster, Nick Andrews, John Saunders, Helen Fifer, Kate Folkard, O Noel Gill, On Behalf Of The Incident Management Team

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Abstract

We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

Original language	English
Number of pages	5
Journal	Eurosurveillance
Volume	24
Issue number	38
DOIs	https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557
Publication status	Published - 19 Sept 2019

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This is the final published version of the article (version of record). It first appeared online via European Centre for Disease Prevention and Control at https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.38.1900557 . Please refer to any applicable terms of use of the publisher.
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Roberts, D. J., Davis, G. S., Cole, M. J., Naik, D., Maru, H., Woodford, N., Muir, P., Horner, P., Simms, I., Thickett, G., Crook, P., Foster, K., Andrews, N., Saunders, J., Fifer, H., Folkard, K., Gill, O. N., & On Behalf Of The Incident Management Team (2019). Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019. Eurosurveillance, 24(38). https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557

@article{b8a9b0e2a5ea4d0fa2bdaa6eeb1b5bae,

title = "Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019",

abstract = "We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.",

author = "Roberts, {David J} and Davis, {Grahame S} and Cole, {Michelle J} and Dixita Naik and Hitiksha Maru and Neil Woodford and Peter Muir and Paddy Horner and Ian Simms and George Thickett and Paul Crook and Kirsty Foster and Nick Andrews and John Saunders and Helen Fifer and Kate Folkard and Gill, {O Noel} and {On Behalf Of The Incident Management Team}",

year = "2019",

month = sep,

day = "19",

doi = "10.2807/1560-7917.ES.2019.24.38.1900557",

language = "English",

volume = "24",

journal = "Eurosurveillance",

issn = "1025-496X",

publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",

number = "38",

}

Roberts, DJ, Davis, GS, Cole, MJ, Naik, D, Maru, H, Woodford, N, Muir, P, Horner, P, Simms, I, Thickett, G, Crook, P, Foster, K, Andrews, N, Saunders, J, Fifer, H, Folkard, K, Gill, ON & On Behalf Of The Incident Management Team 2019, 'Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019', Eurosurveillance, vol. 24, no. 38. https://doi.org/10.2807/1560-7917.ES.2019.24.38.1900557

TY - JOUR

T1 - Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019

AU - Roberts, David J

AU - Davis, Grahame S

AU - Cole, Michelle J

AU - Naik, Dixita

AU - Maru, Hitiksha

AU - Woodford, Neil

AU - Muir, Peter

AU - Horner, Paddy

AU - Simms, Ian

AU - Thickett, George

AU - Crook, Paul

AU - Foster, Kirsty

AU - Andrews, Nick

AU - Saunders, John

AU - Fifer, Helen

AU - Folkard, Kate

AU - Gill, O Noel

AU - On Behalf Of The Incident Management Team, null

PY - 2019/9/19

Y1 - 2019/9/19

N2 - We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

AB - We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

U2 - 10.2807/1560-7917.ES.2019.24.38.1900557

DO - 10.2807/1560-7917.ES.2019.24.38.1900557

M3 - Article (Academic Journal)

C2 - 31552817

SN - 1025-496X

VL - 24

JO - Eurosurveillance

JF - Eurosurveillance

IS - 38

ER -

Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019

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