Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema

Sara J Brown, Aileen Sandilands, Yiwei Zhao, Haihui Liao, Caroline L Relton, Simon J Meggitt, Richard C Trembath, Jonathan N W N Barker, Nick J Reynolds, Heather J Cordell, W H Irwin McLean

Research output: Contribution to journalArticle (Academic Journal)peer-review

89 Citations (Scopus)
Original languageEnglish
Pages (from-to)1591-4
Number of pages4
JournalJournal of Investigative Dermatology
Issue number6
Publication statusPublished - Jun 2008


  • Alleles
  • DNA Mutational Analysis
  • Dermatitis, Atopic
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Intermediate Filament Proteins
  • Models, Statistical
  • Mutation
  • Odds Ratio
  • Phenotype

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