Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema

Sara J Brown; Aileen Sandilands; Yiwei Zhao; Haihui Liao; Caroline L Relton; Simon J Meggitt; Richard C Trembath; Jonathan N W N Barker; Nick J Reynolds; Heather J Cordell; W H Irwin McLean

doi:10.1038/sj.jid.5701206

Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema

Sara J Brown, Aileen Sandilands, Yiwei Zhao, Haihui Liao, Caroline L Relton, Simon J Meggitt, Richard C Trembath, Jonathan N W N Barker, Nick J Reynolds, Heather J Cordell, W H Irwin McLean

Research output: Contribution to journal › Article (Academic Journal) › peer-review

54 Citations (Scopus)

Original language	English
Pages (from-to)	1591-4
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	128
Issue number	6
DOIs	https://doi.org/10.1038/sj.jid.5701206
Publication status	Published - Jun 2008

Keywords

Alleles
DNA Mutational Analysis
Dermatitis, Atopic
Gene Expression Regulation
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Intermediate Filament Proteins
Models, Statistical
Mutation
Odds Ratio
Phenotype

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Brown, S. J., Sandilands, A., Zhao, Y., Liao, H., Relton, C. L., Meggitt, S. J., Trembath, R. C., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., & McLean, W. H. I. (2008). Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema. Journal of Investigative Dermatology, 128(6), 1591-4. https://doi.org/10.1038/sj.jid.5701206

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title = "Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema",

keywords = "Alleles, DNA Mutational Analysis, Dermatitis, Atopic, Gene Expression Regulation, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Intermediate Filament Proteins, Models, Statistical, Mutation, Odds Ratio, Phenotype",

author = "Brown, {Sara J} and Aileen Sandilands and Yiwei Zhao and Haihui Liao and Relton, {Caroline L} and Meggitt, {Simon J} and Trembath, {Richard C} and Barker, {Jonathan N W N} and Reynolds, {Nick J} and Cordell, {Heather J} and McLean, {W H Irwin}",

year = "2008",

month = jun,

doi = "10.1038/sj.jid.5701206",

language = "English",

volume = "128",

pages = "1591--4",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Elsevier Inc.",

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Brown, SJ, Sandilands, A, Zhao, Y, Liao, H, Relton, CL, Meggitt, SJ, Trembath, RC, Barker, JNWN, Reynolds, NJ, Cordell, HJ & McLean, WHI 2008, 'Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema', Journal of Investigative Dermatology, vol. 128, no. 6, pp. 1591-4. https://doi.org/10.1038/sj.jid.5701206

TY - JOUR

T1 - Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema

AU - Brown, Sara J

AU - Sandilands, Aileen

AU - Zhao, Yiwei

AU - Liao, Haihui

AU - Relton, Caroline L

AU - Meggitt, Simon J

AU - Trembath, Richard C

AU - Barker, Jonathan N W N

AU - Reynolds, Nick J

AU - Cordell, Heather J

AU - McLean, W H Irwin

PY - 2008/6

Y1 - 2008/6

KW - Alleles

KW - DNA Mutational Analysis

KW - Dermatitis, Atopic

KW - Gene Expression Regulation

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Intermediate Filament Proteins

KW - Models, Statistical

KW - Mutation

KW - Odds Ratio

KW - Phenotype

U2 - 10.1038/sj.jid.5701206

DO - 10.1038/sj.jid.5701206

M3 - Article (Academic Journal)

C2 - 18094728

SN - 0022-202X

VL - 128

SP - 1591

EP - 1594

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 6

ER -