PRImary care Streptococcal Management (PRISM) study: in vitro study, diagnostic cohorts and a pragmatic adaptive randomised controlled trial with nested qualitative study and cost-effectiveness study

Paul Little, Fd Richard Hobbs, Michael Moore, David Mant, Ian Williamson, Cliodna McNulty, Gemma Lasseter, My Edith Cheng, Geraldine Leydon, Lisa McDermott, David Turner, Rafael Pinedo-Villanueva, James Raftery, Paul Glasziou, Mark Mullee

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

Abstract

Antibiotics are still prescribed to most patients attending primary care with acute sore throat, despite evidence that there is modest benefit overall from antibiotics. Targeting antibiotics using either clinical scoring methods or rapid antigen detection tests (RADTs) could help. However, there is debate about which groups of streptococci are important (particularly Lancefield groups C and G), and uncertainty about the variables that most clearly predict the presence of streptococci.
Original languageEnglish
Pages (from-to)1-102
Number of pages102
JournalHealth Technology Assessment
Volume18
Issue number6
DOIs
Publication statusPublished - Jan 2014

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    Little, P., Hobbs, F. R., Moore, M., Mant, D., Williamson, I., McNulty, C., Lasseter, G., Cheng, M. E., Leydon, G., McDermott, L., Turner, D., Pinedo-Villanueva, R., Raftery, J., Glasziou, P., & Mullee, M. (2014). PRImary care Streptococcal Management (PRISM) study: in vitro study, diagnostic cohorts and a pragmatic adaptive randomised controlled trial with nested qualitative study and cost-effectiveness study. Health Technology Assessment, 18(6), 1-102. https://doi.org/10.3310/hta18060