Primary Incidence of Hepatitis C Virus Infection Among HIV-Infected Men Who Have Sex With Men in San Diego, 2000–2015

Antoine Chaillon, Xiaoying Sun, Edward R. Cachay, David Looney, David Wyles, Richard S. Garfein, Thomas C.S. Martin, Sonia Jain, Sanjay R. Mehta, Davey M. Smith, Susan J. Little, Natasha K. Martin*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)
188 Downloads (Pure)

Abstract

BACKGROUND:
Little is known about the hepatitis C virus (HCV) epidemic among HIV-infected men who have sex with men (HIV+ MSM) in the United States. In this study, we aimed to determine the incidence of primary HCV infection among HIV+ MSM in San Diego, California.

METHODS:
We performed a retrospective cohort analysis of HCV infection among HIV+ MSM attending 2 of the largest HIV clinics in San Diego. Incident HCV infection was assessed among HIV+ MSM with a negative anti-HCV test and subsequent HCV test between 2000 and 2017, with data censored to 2015. HCV reinfection was assessed among HIV+ MSM successfully treated for HCV between 2008 and 2015. Infection/reinfection rates were calculated using person-time methods.

RESULTS:
Among 3068 initially HCV-seronegative HIV+ MSM, 178 new infections occurred over 15 796 person-years, giving an incidence of 1.13 per 100 person-years (/100py; 95% confidence interval [CI], 0.97-1.31). Incidence was stable from 2000 to 2014 (0.83/100py; 95% CI, 0.41-1.48), with an increase to 3.01/100py (95% CI, 1.97-4.42) in 2015 (P = .02). Among 43 successfully treated patients, 3 were reinfected.

CONCLUSIONS:
HCV incidence is high among HIV+ MSM in San Diego, with evidence suggesting a recent increase in 2015. Strong HCV testing guidelines and active prevention efforts among HIV+ MSM are urgently needed that include rapid diagnosis, treatment, and risk reduction.
Original languageEnglish
Article numberofz160
Number of pages7
JournalOpen Forum Infectious Diseases
Volume6
Issue number4
Early online date3 Apr 2019
DOIs
Publication statusE-pub ahead of print - 3 Apr 2019

Keywords

  • HCV
  • HIV
  • Incidence
  • Men who have sex with men

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