This study presents a probabilistic seismic and tsunami damage analysis (PSTDA) due to both earthquake shaking and tsunami inundation from tsunamigenic earthquake events at a coastal community. In particular, this study evaluates the annual exceedance probability (AEP) of seismic and tsunami hazards through earthquake and tsunami modeling that share the same fault sources. Then, estimates of earthquake and tsunami impact on the built environment utilizing fragility functions is predicted spatially. The PSTDA evaluates the combined impacts of earthquake and tsunami through a stochastic approach that accounts for the accumulated damage due to seismic shaking and subsequent tsunami inundation. A case study is setup and applied to Seaside, Oregon, for tsunamigenic earthquake events originating from the Cascadia Subduction Zone (CSZ) in order to illustrate the application of the PSTDA evaluation framework. The PSTDA integrates as a step within a resilience-focused risk-informed decision making process, which includes the assessment of direct and indirect socio-economic losses due to tsunamigenic earthquake events.