Procoagulant platelets: - generation, function and therapeutic targeting in thrombosis

Ejaife Agbani*, Alastair Poole

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

52 Citations (Scopus)
343 Downloads (Pure)

Abstract

Current understanding of how platelets localise coagulation to wound sites has come mainly from studies of a subpopulation of activated platelets. In this review we summarise data from the last four decades which has described these platelets with a range of descriptive titles and attributes. We identify striking overlaps in the reported characteristics of these platelets which imply a single subpopulation of versatile platelets, and thus suggest that their commonality requires unification of their description. We therefore propose the term procoagulant platelet as the unifying terminology. We discuss the agonist requirements and molecular drivers for the dramatic morphological transformation platelets undergo when becoming procoagulant. Finally, we provide perspectives on the biomarker potential of procoagulant platelets for thrombotic events, as well as on the possible clinical benefits of inhibitors of carbonic anhydrase enzymes and the water channel Aquaporin-1 for targeting this subpopulation of platelets as antiprocoagulant antithrombotics.
Original languageEnglish
Pages (from-to)2171-2179
Number of pages9
JournalBlood
Volume130
Issue number20
Early online date27 Sep 2017
DOIs
Publication statusPublished - 16 Nov 2017

Keywords

  • Ballooning
  • Procoagulant platelets
  • Mitochondrial permeability
  • procoagulant-spreading

Fingerprint Dive into the research topics of 'Procoagulant platelets: - generation, function and therapeutic targeting in thrombosis'. Together they form a unique fingerprint.

Cite this