Production of a murine monoclonal antibody to the low-incidence red cell antigen Wra: characterisation and comparison with human anti-Wra

S M Ring, C A Green, D M Swallow, P Tippett

Research output: Contribution to journalArticle (Academic Journal)peer-review

6 Citations (Scopus)

Abstract

The production of a monoclonal antibody which detects the low-incidence red cell antigen Wra is described. The antibody (BGU1-WR) was isolated following immunization of BALB/tk mice with Wr(a+) cells. BGU1-WR is an IgG1 antibody and reacted in a manner similar to human polyclonal anti-Wra with untreated, protease treated and chemically modified Wr(a+) cells.

Original languageEnglish
Pages (from-to)222-5
Number of pages4
JournalVox sanguinis
Volume67
Issue number2
Publication statusPublished - 1994

Keywords

  • Animals
  • Antibodies, Monoclonal
  • Erythrocytes
  • Female
  • Hemagglutination Tests
  • Humans
  • Incidence
  • Isoantigens
  • Mice
  • Mice, Inbred BALB C
  • Species Specificity

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