Production of a murine monoclonal antibody to the low-incidence red cell antigen Wra: characterisation and comparison with human anti-Wra

S M Ring; C A Green; D M Swallow; P Tippett

Production of a murine monoclonal antibody to the low-incidence red cell antigen Wra: characterisation and comparison with human anti-Wra

S M Ring, C A Green, D M Swallow, P Tippett

Research output: Contribution to journal › Article (Academic Journal) › peer-review

6 Citations (Scopus)

Abstract

The production of a monoclonal antibody which detects the low-incidence red cell antigen Wra is described. The antibody (BGU1-WR) was isolated following immunization of BALB/tk mice with Wr(a+) cells. BGU1-WR is an IgG1 antibody and reacted in a manner similar to human polyclonal anti-Wra with untreated, protease treated and chemically modified Wr(a+) cells.

Original language	English
Pages (from-to)	222-5
Number of pages	4
Journal	Vox sanguinis
Volume	67
Issue number	2
Publication status	Published - 1994

Keywords

Animals
Antibodies, Monoclonal
Erythrocytes
Female
Hemagglutination Tests
Humans
Incidence
Isoantigens
Mice
Mice, Inbred BALB C
Species Specificity

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title = "Production of a murine monoclonal antibody to the low-incidence red cell antigen Wra: characterisation and comparison with human anti-Wra",

abstract = "The production of a monoclonal antibody which detects the low-incidence red cell antigen Wra is described. The antibody (BGU1-WR) was isolated following immunization of BALB/tk mice with Wr(a+) cells. BGU1-WR is an IgG1 antibody and reacted in a manner similar to human polyclonal anti-Wra with untreated, protease treated and chemically modified Wr(a+) cells.",

keywords = "Animals, Antibodies, Monoclonal, Erythrocytes, Female, Hemagglutination Tests, Humans, Incidence, Isoantigens, Mice, Mice, Inbred BALB C, Species Specificity",

author = "Ring, {S M} and Green, {C A} and Swallow, {D M} and P Tippett",

year = "1994",

language = "English",

volume = "67",

pages = "222--5",

journal = "Vox Sang",

issn = "0042-9007",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - Production of a murine monoclonal antibody to the low-incidence red cell antigen Wra

T2 - characterisation and comparison with human anti-Wra

AU - Ring, S M

AU - Green, C A

AU - Swallow, D M

AU - Tippett, P

PY - 1994

Y1 - 1994

N2 - The production of a monoclonal antibody which detects the low-incidence red cell antigen Wra is described. The antibody (BGU1-WR) was isolated following immunization of BALB/tk mice with Wr(a+) cells. BGU1-WR is an IgG1 antibody and reacted in a manner similar to human polyclonal anti-Wra with untreated, protease treated and chemically modified Wr(a+) cells.

AB - The production of a monoclonal antibody which detects the low-incidence red cell antigen Wra is described. The antibody (BGU1-WR) was isolated following immunization of BALB/tk mice with Wr(a+) cells. BGU1-WR is an IgG1 antibody and reacted in a manner similar to human polyclonal anti-Wra with untreated, protease treated and chemically modified Wr(a+) cells.

KW - Animals

KW - Antibodies, Monoclonal

KW - Erythrocytes

KW - Female

KW - Hemagglutination Tests

KW - Humans

KW - Incidence

KW - Isoantigens

KW - Mice

KW - Mice, Inbred BALB C

KW - Species Specificity

M3 - Article (Academic Journal)

C2 - 7801616

VL - 67

SP - 222

EP - 225

JO - Vox Sang

JF - Vox Sang

SN - 0042-9007

IS - 2

ER -