TY - JOUR
T1 - Prognostic and predictive biomarkers in adult and pediatric gliomas
T2 - toward personalized treatment
AU - Haynes, Harry R
AU - Camelo-Piragua, Sandra
AU - Kurian, Kathreena M
PY - 2014
Y1 - 2014
N2 - It is increasingly clear that both adult and pediatric glial tumor entities represent collections of neoplastic lesions, each with individual pathological molecular events and treatment responses. In this review, we discuss the current prognostic biomarkers validated for clinical use or with future clinical validity for gliomas. Accurate prognostication is crucial for managing patients as treatments may be associated with high morbidity and the benefits of high risk interventions must be judged by the treating clinicians. We also review biomarkers with predictive validity, which may become clinically relevant with the development of targeted therapies for adult and pediatric gliomas.
AB - It is increasingly clear that both adult and pediatric glial tumor entities represent collections of neoplastic lesions, each with individual pathological molecular events and treatment responses. In this review, we discuss the current prognostic biomarkers validated for clinical use or with future clinical validity for gliomas. Accurate prognostication is crucial for managing patients as treatments may be associated with high morbidity and the benefits of high risk interventions must be judged by the treating clinicians. We also review biomarkers with predictive validity, which may become clinically relevant with the development of targeted therapies for adult and pediatric gliomas.
U2 - 10.3389/fonc.2014.00047
DO - 10.3389/fonc.2014.00047
M3 - Article (Academic Journal)
C2 - 24716189
VL - 4
SP - 47
JO - Frontiers in Oncology
JF - Frontiers in Oncology
SN - 2234-943X
ER -