Prognostic criteria in rheumatoid arthritis: Can we predict which patients will require specific anti-rheumatoid treatment?

J. R. Kirwan*, B. Quilty

*Corresponding author for this work

    Research output: Contribution to journalReview article (Academic Journal)

    26 Citations (Scopus)

    Abstract

    Longitudinal studies of rheumatoid arthritis (RA) have shown that joint damage often occurs early in the disease. Therefore, the early treatment of RA with 'disease modifying' drugs is gaining acceptance. However, many patients presenting with inflammatory polyarthropathy will follow a benign course. Rheumatologists need to be able to target the use of potentially toxic drugs to those cases where the benefits clearly outweigh the risks. This approach requires reliable assessment of the prognosis at an early stage in the disease process. We have critically evaluated a large number of published studies which claim to provide clinically useful information regarding the prognosis of RA. Conclusion. The majority of studies have methodological flaws which limit their value. A small number of published studies exist which provide useful data about estimating the prognosis of RA. Currently evaluated prognostic indicators are only moderately successful and there is an urgent need for methodologically sound research in this area.

    Original languageEnglish
    Pages (from-to)S15-S25
    Number of pages11
    JournalClinical and Experimental Rheumatology
    Volume15
    Issue numberSUPPL. 17
    Publication statusPublished - 1 May 1997

    Keywords

    • Early arthritis
    • Polyarthropathy
    • Prediction
    • Prognosis
    • Rheumatoid arthritis
    • Rheumatoid factor

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