Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas

Yosuke Hashimoto, Marek Skacel, Ian C Lavery, Abir L Mukherjee, Graham Casey, Josephine C Adams

Research output: Contribution to journalArticle (Academic Journal)peer-review

109 Citations (Scopus)

Abstract

Fascin is an actin bundling protein with roles in the formation of cell protrusions and motility of mesenchymal and neuronal cells. Fascin is normally low or absent from epithelia, but is upregulated in several epithelial neoplasms where it may contribute to an invasive phenotype. Here, we report on the prevalence and potential clinical significance of fascin expression in relation to the progression of colorectal adenocarcinoma and to tumor cell proliferation as measured by Ki67 index.
Original languageEnglish
Pages (from-to)241
JournalBMC Cancer
Volume6
DOIs
Publication statusPublished - 2006

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