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Programmed assembly of synthetic protocells into thermoresponsive prototissues

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1145-1153
Number of pages9
JournalNature Materials
Issue number12
Early online date8 Oct 2018
DateAccepted/In press - 30 Aug 2018
DateE-pub ahead of print - 8 Oct 2018
DatePublished (current) - 1 Dec 2018


Although several new types of synthetic cell-like entities are now available, their structural integration into spatially interlinked prototissues that communicate and display coordinated functions remains a considerable challenge. Here we describe the programmed assembly of synthetic prototissue constructs based on the bio-orthogonal adhesion of a spatially confined binary community of protein–polymer protocells, termed proteinosomes. The thermoresponsive properties of the interlinked proteinosomes are used collectively to generate prototissue spheroids capable of reversible contractions that can be enzymatically modulated and exploited for mechanochemical transduction. Overall, our methodology opens up a route to the fabrication of artificial tissue-like materials capable of collective behaviours, and addresses important emerging challenges in bottom-up synthetic biology and bioinspired engineering.

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  • BrisSynBio
  • Bristol BioDesign Institute

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Nature at DOI: 10.1038/s41563-018-0183-5. Please refer to any applicable terms of use of the publisher

    Accepted author manuscript, 1.63 MB, PDF document


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