Prolonged ketamine infusion as a therapy for complex regional pain syndrome: Synergism with antagonism?

Anthony E. Pickering*, Candida S. McCabe

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)
373 Downloads (Pure)

Abstract

Complex regional pain syndrome (CRPS) remains a troubling and often refractory pain condition for which the existing treatments are inadequate. The review by Niesters et al in this journal highlights the interesting findings of several recent studies of the NMDA receptor antagonist ketamine in the treatment of CRPS. These studies report a robust analgesic effect that outlasts the period of infusion by weeks. However set against these positive findings are the issues presented by Ketamine pharmacokinetics, side effects and also the observation that these analgesic benefits are not mirrored by improvements in function or affect. In this commentary we consider the wider perspective of the potential for developing and evaluating this sort of NMDA antagonist therapy for the long-term management of CRPS patients.
Original languageEnglish
Article number3992840
Pages (from-to)233-238
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume77
Issue number2
DOIs
Publication statusPublished - 1 Feb 2014

Bibliographical note

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