Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Leonid N. Maslov; Igor Khaliulin; Peter R. Oeltgen; Natalia V. Naryzhnaya; Jian Ming Pei; Stephen A. Brown; Yury B. Lishmanov; James M. Downey

doi:10.1002/med.21395

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Leonid N. Maslov
, Igor Khaliulin^*
, Peter R. Oeltgen
, Natalia V. Naryzhnaya
, Jian Ming Pei
, Stephen A. Brown
, Yury B. Lishmanov
, James M. Downey

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

53 Citations (Scopus)

463 Downloads (Pure)

Abstract

It has now been demonstrated that the μ, δ₁, δ₂, and κ₁ opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.

Original language	English
Pages (from-to)	871–923
Number of pages	53
Journal	Medicinal Research Reviews
Volume	36
Issue number	5
Early online date	16 May 2016
DOIs	https://doi.org/10.1002/med.21395
Publication status	Published - Sept 2016

Keywords

Cardioprotection
Heart
Ischemia/reperfusion injury
Opioids
Signal transduction

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title = "Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists",

abstract = "It has now been demonstrated that the μ, δ1, δ2, and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.",

keywords = "Cardioprotection, Heart, Ischemia/reperfusion injury, Opioids, Signal transduction",

author = "Maslov, \{Leonid N.\} and Igor Khaliulin and Oeltgen, \{Peter R.\} and Naryzhnaya, \{Natalia V.\} and Pei, \{Jian Ming\} and Brown, \{Stephen A.\} and Lishmanov, \{Yury B.\} and Downey, \{James M.\}",

year = "2016",

month = sep,

doi = "10.1002/med.21395",

language = "English",

volume = "36",

pages = "871–923",

journal = "Medicinal Research Reviews",

issn = "1098-1128",

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AU - Maslov, Leonid N.

AU - Khaliulin, Igor

AU - Oeltgen, Peter R.

AU - Naryzhnaya, Natalia V.

AU - Pei, Jian Ming

AU - Brown, Stephen A.

AU - Lishmanov, Yury B.

AU - Downey, James M.

PY - 2016/9

Y1 - 2016/9

N2 - It has now been demonstrated that the μ, δ1, δ2, and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.

AB - It has now been demonstrated that the μ, δ1, δ2, and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.

KW - Cardioprotection

KW - Heart

KW - Ischemia/reperfusion injury

KW - Opioids

KW - Signal transduction

UR - https://www.scopus.com/pages/publications/84971016435

U2 - 10.1002/med.21395

DO - 10.1002/med.21395

M3 - Article (Academic Journal)

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JO - Medicinal Research Reviews

JF - Medicinal Research Reviews

IS - 5

ER -

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

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Role of cyclicAMP/PKA/Epac signalling in cardioprotection

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Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

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Role of cyclicAMP/PKA/Epac signalling in cardioprotection

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