Prostate cancer is the second most common cancer in men worldwide, accounting for an estimated 1.1 million cases diagnosed in 2012 (www.globocan.iarc.fr). Currently, there is a lack of speciﬁc guidance on supportive care for men with prostate cancer. This article describes a qualitative systematic review and synthesis examining men’s experience of and need for supportive care. Seven databases were searched; 20 journal articles were identiﬁed and critically appraised. A thematic synthesis was conducted in which descriptive themes were drawn out of the data. These were peer support, support from partner, online support, cancer specialist nurse support,self-care, communication with health professionals, unmet needs (emotional support, information needs, support for treatment-induced side effects of incontinence and erectile dysfunction) and men’s suggestions for improved delivery of supportive care. This was followed by the development of overarching analytic themes which were:uncertainty, reframing, and the timing of receiving treatment, information and support. Our results show that the most valued form of support men experienced following diagnosis was one-to-one peer support and support from partners. This review highlights the need for improved access to cancer specialist nurses throughout the care pathway, individually tailored supportive care and psycho-sexual support for treatment side effects.