Protection from clinical peripheral sensory neuropathy in Alström syndrome in contrast to early-onset type 2 diabetes

RB Paisey, RM Paisey, MP Thomson, L Bower, P Maffei, JPH Shield, S Barnett, JD Marshall

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)

Abstract

OBJECTIVE: Alström syndrome, with type 2 diabetes, and blindness could confer a high risk of foot ulceration. Clinical testing for neuropathy in Alström syndrome and matched young-onset type 2 diabetic subjects was therefore undertaken. RESEARCH DESIGN AND METHODS: Fifty-eight subjects with Alström syndrome (18 insulin-resistant nondiabetic and 40 diabetic; aged 8-43 years) and 30 young-onset diabetic subjects (aged 13-35 years) were studied. Neuropathy symptom questionnaires were administered. Graded monofilament and 128-MHz tuning fork vibration perception were assessed in both feet. RESULTS: Neuropathic symptoms, loss of monofilament, and/or vibration perception were reported by 12 of the 30 young-onset type 2 diabetic subjects (6 had neuropathic ulceration) but none of the subjects with Alström syndrome. CONCLUSIONS: The striking preservation of protective foot sensation in Alström syndrome may provide a clue to the causes of differential susceptibility to neuropathy in the wider diabetic population.
Translated title of the contributionProtection from clinical peripheral sensory neuropathy in Alström syndrome in contrast to early-onset type 2 diabetes
Original languageEnglish
Pages (from-to)462 - 464
Number of pages3
JournalDiabetes Care
Volume32(3)
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Dive into the research topics of 'Protection from clinical peripheral sensory neuropathy in Alström syndrome in contrast to early-onset type 2 diabetes'. Together they form a unique fingerprint.

Cite this