Protein kinase Calpha: disease regulator and therapeutic target

O Konopatskaya, AW Poole

Research output: Contribution to journalArticle (Academic Journal)

85 Citations (Scopus)

Abstract

Protein kinase Calpha (PKCalpha) is a member of the AGC (which includes PKD, PKG and PKC) family of serine/threonine protein kinases that is widely expressed in mammalian tissues. It is closely related in structure, function and regulation to other members of the protein kinase C family, but has specific functions within the tissues in which it is expressed. There is substantial recent evidence, from gene knockout studies in particular, that PKCalpha activity regulates cardiac contractility, atherogenesis, cancer and arterial thrombosis. Selective targeting of PKCalpha therefore has potential therapeutic value in a wide variety of disease states, although will be technically complicated by the ubiquitous expression and multiple functions of the molecule.
Translated title of the contributionProtein kinase Calpha: disease regulator and therapeutic target
Original languageEnglish
Pages (from-to)8 - 14
JournalTrends in Pharmacological Sciences
Volume31(1)
Publication statusPublished - Jan 2010

Bibliographical note

Author of Publication Reviewed: Konopatskaya O, Poole AW

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