Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product

T Matsumoto, S Hess, H Kajiyama, T Sakairi, MA Saleem, PW Mathieson, Y Nojima, JB Kopp

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Abstract

The podocyte secretory proteome may influence the phenotype of adjacent podocytes, endothelial cells, parietal epithelial cells, and tubular epithelial cells but has not been systematically characterized. We have initiated studies to characterize this proteome, with the goal of further understanding the podocyte cell biology. We cultured differentiated conditionally immortalized human podocytes and subjected the proteins in conditioned medium to mass spectrometry. At a false discovery rate of
Translated title of the contributionProteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product
Original languageEnglish
Pages (from-to)F776 - F784
Number of pages9
JournalAJP - Renal Physiology
Volume299(4)
DOIs
Publication statusPublished - Oct 2010

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