Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression

Robert C Culverhouse, Lucy Bowes, Naomi Breslau, John I Nurnberger, Margit Burmeister, David M Fergusson, Marcus Munafò, Nancy L Saccone, Laura J Bierut

Research output: Contribution to journalArticle (Academic Journal)peer-review

32 Citations (Scopus)


Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and stressful life events affecting the risk for depression, others report a main effect of 5-HTTLPR variation on depression, while others find no evidence for either a main or interaction effect. Meta-analyses of multiple studies have also reached differing conclusions.Method/designTo improve understanding of the combined roles of 5-HTTLPR variation and stress in the development of depression, we are conducting a meta-analysis of multiple independent datasets. This coordinated approach utilizes new analyses performed with centrally-developed, standardized scripts. This publication documents the protocol for this collaborative, consortium-based meta-analysis of 5-HTTLPR variation, stress, and depression.Study eligibility criteria: Our goal is to invite all datasets, published or unpublished, with 5-HTTLPR genotype and assessments of stress and depression for at least 300 subjects. This inclusive approach is to minimize potential impact from publication bias.
Original languageEnglish
Pages (from-to)304
JournalBMC Psychiatry
Issue number1
Publication statusPublished - 12 Nov 2013

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol


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