Projects per year
Methods and analysis The coprimary outcomes are (1) practice rate of dispensed amoxicillin and macrolide antibiotics, (2) hospital admission rate for RTI using routinely collected data by Clinical Commissioning Groups (CCGs). Data will be collected for children aged 0–9 years registered at 310 practices (155 intervention, 155 usual care) over a 12-month period. Recruitment and randomisation of practices (using the Egton Medical Information Systems web data management system) is conducted via each CCG stratified for children registered and baseline dispensing rates of each practice. Secondary outcomes will explore intervention effect modifiers. Qualitative interviews will explore intervention usage. The economic evaluation will be limited to a between-arm comparison in a cost–consequence analysis.
Ethics and dissemination Research ethics approval was given by London-Camden and Kings Cross Research Ethics Committee (ref:18/LO/0345). This manuscript refers to protocol V.4.0. Results will be disseminated through peer-reviewed journals and international conferences.
Trial registration number ISRCTN11405239.
Bibliographical noteFunding Information:
The trial is supported by the Bristol Randomised Trials Collaboration (BRTC). The trial will conform to the BRTC standard operating procedures. The BRTC central research team will help prepare the trial documentation and data collection forms, specify the randomisation scheme, develop and maintain the study database, check data quality, monitor recruitment and carry out analyses in collaboration with the investigators. Both an independent trials steering committee (TSC) and data monitoring committee (DMC) will be appointed.
- Centre for Academic Primary Care
- primary care
- randomised controlled trial
FingerprintDive into the research topics of 'Protocol for an ‘efficient design’ cluster randomised controlled trial to evaluate a complex intervention to improve antibiotic prescribing for CHIldren presenting to primary care with acute COugh and respiratory tract infection: the CHICO study'. Together they form a unique fingerprint.
- 1 Finished
CHICO: A clinical effectiveness investigation of a multi-faceted intervention (incorporating a prognostic algorithm) to improve management of antibiotics for CHIldren presenting to primary care with acute COugh and respiratory tract infection
31/03/18 → 31/03/22