Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial

Rathie Rajendram, Richard W J Lee, Mike J Potts, Geoff E Rose, Rajni Jain, Jane M Olver, Fion Bremner, Steven Hurel, Anne Cook, Rao Gattamaneni, Marjorie Tomlinson, Nicholas Plowman, Catey Bunce, Sandra P Hollinghurst, Laura Kingston, Sue Jackson, Andrew D Dick, Nichola Rumsey, Olivia C Morris, Colin M DayanJimmy M Uddin

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Medical management of thyroid eye disease remains controversial due to a paucity of high quality evidence on long-term treatment outcomes. Glucocorticoids are known to be effective initially but have significant side-effects with long-term use and recrudescence can occur on cessation. Current evidence is conflicting on the efficacy of radiotherapy and non-steroid systemic immunosuppression, and the majority of previous studies have been retrospective, uncontrolled, small or poorly designed.The Combined Immunosuppression and Radiotherapy in Thyroid Eye Disease (CIRTED) trial was designed to investigate the efficacy of radiotherapy and azathioprine in combination with a standard course of oral prednisolone in patients with active thyroid eye disease.
Translated title of the contributionProtocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial
Original languageEnglish
Pages (from-to)6 - 6
Number of pages1
JournalTrials
Volume9
DOIs
Publication statusPublished - Jan 2008

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