Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial

Rathie Rajendram; Richard W J Lee; Mike J Potts; Geoff E Rose; Rajni Jain; Jane M Olver; Fion Bremner; Steven Hurel; Anne Cook; Rao Gattamaneni; Marjorie Tomlinson; Nicholas Plowman; Catey Bunce; Sandra P Hollinghurst; Laura Kingston; Sue Jackson; Andrew D Dick; Nichola Rumsey; Olivia C Morris; Colin M Dayan; Jimmy M Uddin

doi:10.1186/1745-6215-9-6

Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial

Rathie Rajendram, Richard W J Lee, Mike J Potts, Geoff E Rose, Rajni Jain, Jane M Olver, Fion Bremner, Steven Hurel, Anne Cook, Rao Gattamaneni, Marjorie Tomlinson, Nicholas Plowman, Catey Bunce, Sandra P Hollinghurst, Laura Kingston, Sue Jackson, Andrew D Dick, Nichola Rumsey, Olivia C Morris, Colin M DayanJimmy M Uddin

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Medical management of thyroid eye disease remains controversial due to a paucity of high quality evidence on long-term treatment outcomes. Glucocorticoids are known to be effective initially but have significant side-effects with long-term use and recrudescence can occur on cessation. Current evidence is conflicting on the efficacy of radiotherapy and non-steroid systemic immunosuppression, and the majority of previous studies have been retrospective, uncontrolled, small or poorly designed.The Combined Immunosuppression and Radiotherapy in Thyroid Eye Disease (CIRTED) trial was designed to investigate the efficacy of radiotherapy and azathioprine in combination with a standard course of oral prednisolone in patients with active thyroid eye disease.

Translated title of the contribution	Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial
Original language	English
Pages (from-to)	6 - 6
Number of pages	1
Journal	Trials
Volume	9
DOIs	https://doi.org/10.1186/1745-6215-9-6
Publication status	Published - Jan 2008

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Rajendram, R., Lee, R. W. J., Potts, M. J., Rose, G. E., Jain, R., Olver, J. M., Bremner, F., Hurel, S., Cook, A., Gattamaneni, R., Tomlinson, M., Plowman, N., Bunce, C., Hollinghurst, S. P., Kingston, L., Jackson, S., Dick, A. D., Rumsey, N., Morris, O. C., ... Uddin, J. M. (2008). Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial. Trials, 9, 6 - 6. https://doi.org/10.1186/1745-6215-9-6

@article{1673cc8d62f8466bba63b993e6c38898,

title = "Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial",

abstract = "Medical management of thyroid eye disease remains controversial due to a paucity of high quality evidence on long-term treatment outcomes. Glucocorticoids are known to be effective initially but have significant side-effects with long-term use and recrudescence can occur on cessation. Current evidence is conflicting on the efficacy of radiotherapy and non-steroid systemic immunosuppression, and the majority of previous studies have been retrospective, uncontrolled, small or poorly designed.The Combined Immunosuppression and Radiotherapy in Thyroid Eye Disease (CIRTED) trial was designed to investigate the efficacy of radiotherapy and azathioprine in combination with a standard course of oral prednisolone in patients with active thyroid eye disease.",

author = "Rathie Rajendram and Lee, {Richard W J} and Potts, {Mike J} and Rose, {Geoff E} and Rajni Jain and Olver, {Jane M} and Fion Bremner and Steven Hurel and Anne Cook and Rao Gattamaneni and Marjorie Tomlinson and Nicholas Plowman and Catey Bunce and Hollinghurst, {Sandra P} and Laura Kingston and Sue Jackson and Dick, {Andrew D} and Nichola Rumsey and Morris, {Olivia C} and Dayan, {Colin M} and Uddin, {Jimmy M}",

year = "2008",

month = jan,

doi = "10.1186/1745-6215-9-6",

language = "English",

volume = "9",

pages = "6 -- 6",

journal = "Trials",

issn = "1745-6215",

publisher = "BioMed Central",

}

Rajendram, R, Lee, RWJ, Potts, MJ, Rose, GE, Jain, R, Olver, JM, Bremner, F, Hurel, S, Cook, A, Gattamaneni, R, Tomlinson, M, Plowman, N, Bunce, C, Hollinghurst, SP, Kingston, L, Jackson, S, Dick, AD, Rumsey, N, Morris, OC, Dayan, CM & Uddin, JM 2008, 'Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial', Trials, vol. 9, pp. 6 - 6. https://doi.org/10.1186/1745-6215-9-6

TY - JOUR

T1 - Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial

AU - Rajendram, Rathie

AU - Lee, Richard W J

AU - Potts, Mike J

AU - Rose, Geoff E

AU - Jain, Rajni

AU - Olver, Jane M

AU - Bremner, Fion

AU - Hurel, Steven

AU - Cook, Anne

AU - Gattamaneni, Rao

AU - Tomlinson, Marjorie

AU - Plowman, Nicholas

AU - Bunce, Catey

AU - Hollinghurst, Sandra P

AU - Kingston, Laura

AU - Jackson, Sue

AU - Dick, Andrew D

AU - Rumsey, Nichola

AU - Morris, Olivia C

AU - Dayan, Colin M

AU - Uddin, Jimmy M

PY - 2008/1

Y1 - 2008/1

N2 - Medical management of thyroid eye disease remains controversial due to a paucity of high quality evidence on long-term treatment outcomes. Glucocorticoids are known to be effective initially but have significant side-effects with long-term use and recrudescence can occur on cessation. Current evidence is conflicting on the efficacy of radiotherapy and non-steroid systemic immunosuppression, and the majority of previous studies have been retrospective, uncontrolled, small or poorly designed.The Combined Immunosuppression and Radiotherapy in Thyroid Eye Disease (CIRTED) trial was designed to investigate the efficacy of radiotherapy and azathioprine in combination with a standard course of oral prednisolone in patients with active thyroid eye disease.

AB - Medical management of thyroid eye disease remains controversial due to a paucity of high quality evidence on long-term treatment outcomes. Glucocorticoids are known to be effective initially but have significant side-effects with long-term use and recrudescence can occur on cessation. Current evidence is conflicting on the efficacy of radiotherapy and non-steroid systemic immunosuppression, and the majority of previous studies have been retrospective, uncontrolled, small or poorly designed.The Combined Immunosuppression and Radiotherapy in Thyroid Eye Disease (CIRTED) trial was designed to investigate the efficacy of radiotherapy and azathioprine in combination with a standard course of oral prednisolone in patients with active thyroid eye disease.

U2 - 10.1186/1745-6215-9-6

DO - 10.1186/1745-6215-9-6

M3 - Article (Academic Journal)

C2 - 18237441

SN - 1745-6215

VL - 9

SP - 6

EP - 6

JO - Trials

JF - Trials

ER -

Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial

Abstract

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