Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus

Azzedine Abdi, Nicolas Mallet, Foad Y. Mohamed, Andrew Sharott, Paul D. Dodson, Kouichi C. Nakamura, Sana Suri, Sophie V. Avery, Joseph T. Larvin, Farid N. Garas, Shady N. Garas, Federica Vinciati, Stéphanie Morin, Erwan Bezard, Jérôme Baufreton, Peter J. Magill*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

160 Citations (Scopus)


Studies in dopamine-depleted rats indicate that the external globus pallidus (GPe) contains two main types of GABAergic projection cell; so-called “prototypic” and “arkypallidal” neurons. Here, we used correlative anatomical and electrophysiological approaches in rats to determine whether and how this dichotomous organization applies to the dopamine-intact GPe. Prototypic neurons coexpressed the transcription factors Nkx2-1 and Lhx6, comprised approximately two-thirds of all GPe neurons, and were the major GPe cell type innervating the subthalamic nucleus (STN). In contrast, arkypallidal neurons expressed the transcription factor FoxP2, constituted just over one-fourth of GPe neurons, and innervated the striatum but not STN. In anesthetized dopamine-intact rats, molecularly identified prototypic neurons fired at relatively high rates and with high regularity, regardless of brain state (slow-wave activity or spontaneous activation). On average, arkypallidal neurons fired at lower rates and regularities than prototypic neurons, and the two cell types could be further distinguished by the temporal coupling of their firing to ongoing cortical oscillations. Complementing the activity differences observed in vivo, the autonomous firing of identified arkypallidal neurons in vitro was slower and more variable than that of prototypic neurons, which tallied with arkypallidal neurons displaying lower amplitudes of a “persistent” sodium current important for such pacemaking. Arkypallidal neurons also exhibited weaker driven and rebound firing compared with prototypic neurons. In conclusion, our data support the concept that a dichotomous functional organization, as actioned by arkypallidal and prototypic neurons with specialized molecular, structural, and physiological properties, is fundamental to the operations of the dopamine-intact GPe.

Original languageEnglish
Pages (from-to)6667-6688
Number of pages22
JournalJournal of Neuroscience
Issue number17
Publication statusPublished - 29 Apr 2015


  • Anatomy
  • Arkypallidal
  • Basal ganglia
  • Electrophysiology
  • Globus pallidus
  • Transcription factor


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