Psychopathology and cognition in children with 22q11.2 deletion syndrome

Maria Niarchou, Stanley Zammit, Stephanie Helena Maria van Goozen, Anita Thapar, Hayley Tierling, Michael John Owen, Marianne Bernadette van den Bree

Research output: Contribution to journalArticle (Academic Journal)peer-review

45 Citations (Scopus)
239 Downloads (Pure)

Abstract

BACKGROUND: Children with 22q11.2 deletion syndrome (22q11.2DS) have been reported to have high rates of cognitive and psychiatric problems. AIMS: To establish the nature and prevalence of psychiatric disorder and neurocognitive impairment in children with 22q11.2DS and test whether risk of psychopathology is mediated by the children's intellectual impairment. METHOD: Neurocognition and psychopathology were assessed in 80 children with 22q11.2DS (mean age 10.2 years, s.d. = 2.1) and 39 sibling controls (mean age 10.9 years, s.d. = 2.0). RESULTS: More than half (54 of children with 22q11.2DS met diagnostic criteria for one or more DSM-IV-TR psychiatric disorder. These children had lower IQ (mean 76.8, s.d. = 13.0) than controls (mean 108.6, s.d. = 15.2) (P
Original languageEnglish
Pages (from-to)46-54
Number of pages9
JournalBritish Journal of Psychiatry
Volume204
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014

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