Psychopathology and cognition in children with 22q11.2 deletion syndrome

Maria Niarchou; Stanley Zammit; Stephanie Helena Maria van Goozen; Anita Thapar; Hayley Tierling; Michael John Owen; Marianne Bernadette van den Bree

doi:10.1192/bjp.bp.113.132324

Psychopathology and cognition in children with 22q11.2 deletion syndrome

Maria Niarchou, Stanley Zammit, Stephanie Helena Maria van Goozen, Anita Thapar, Hayley Tierling, Michael John Owen, Marianne Bernadette van den Bree

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Abstract

BACKGROUND: Children with 22q11.2 deletion syndrome (22q11.2DS) have been reported to have high rates of cognitive and psychiatric problems. AIMS: To establish the nature and prevalence of psychiatric disorder and neurocognitive impairment in children with 22q11.2DS and test whether risk of psychopathology is mediated by the children's intellectual impairment. METHOD: Neurocognition and psychopathology were assessed in 80 children with 22q11.2DS (mean age 10.2 years, s.d. = 2.1) and 39 sibling controls (mean age 10.9 years, s.d. = 2.0). RESULTS: More than half (54 of children with 22q11.2DS met diagnostic criteria for one or more DSM-IV-TR psychiatric disorder. These children had lower IQ (mean 76.8, s.d. = 13.0) than controls (mean 108.6, s.d. = 15.2) (P

Original language	English
Pages (from-to)	46-54
Number of pages	9
Journal	British Journal of Psychiatry
Volume	204
Issue number	1
DOIs	https://doi.org/10.1192/bjp.bp.113.132324
Publication status	Published - 1 Jan 2014

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title = "Psychopathology and cognition in children with 22q11.2 deletion syndrome",

abstract = "BACKGROUND: Children with 22q11.2 deletion syndrome (22q11.2DS) have been reported to have high rates of cognitive and psychiatric problems. AIMS: To establish the nature and prevalence of psychiatric disorder and neurocognitive impairment in children with 22q11.2DS and test whether risk of psychopathology is mediated by the children's intellectual impairment. METHOD: Neurocognition and psychopathology were assessed in 80 children with 22q11.2DS (mean age 10.2 years, s.d. = 2.1) and 39 sibling controls (mean age 10.9 years, s.d. = 2.0). RESULTS: More than half (54 of children with 22q11.2DS met diagnostic criteria for one or more DSM-IV-TR psychiatric disorder. These children had lower IQ (mean 76.8, s.d. = 13.0) than controls (mean 108.6, s.d. = 15.2) (P",

author = "Maria Niarchou and Stanley Zammit and Goozen, \{Stephanie Helena Maria van\} and Anita Thapar and Hayley Tierling and Owen, \{Michael John\} and Bree, \{Marianne Bernadette van den\}",

year = "2014",

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doi = "10.1192/bjp.bp.113.132324",

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T1 - Psychopathology and cognition in children with 22q11.2 deletion syndrome

AU - Niarchou, Maria

AU - Zammit, Stanley

AU - Goozen, Stephanie Helena Maria van

AU - Thapar, Anita

AU - Tierling, Hayley

AU - Owen, Michael John

AU - Bree, Marianne Bernadette van den

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND: Children with 22q11.2 deletion syndrome (22q11.2DS) have been reported to have high rates of cognitive and psychiatric problems. AIMS: To establish the nature and prevalence of psychiatric disorder and neurocognitive impairment in children with 22q11.2DS and test whether risk of psychopathology is mediated by the children's intellectual impairment. METHOD: Neurocognition and psychopathology were assessed in 80 children with 22q11.2DS (mean age 10.2 years, s.d. = 2.1) and 39 sibling controls (mean age 10.9 years, s.d. = 2.0). RESULTS: More than half (54 of children with 22q11.2DS met diagnostic criteria for one or more DSM-IV-TR psychiatric disorder. These children had lower IQ (mean 76.8, s.d. = 13.0) than controls (mean 108.6, s.d. = 15.2) (P

AB - BACKGROUND: Children with 22q11.2 deletion syndrome (22q11.2DS) have been reported to have high rates of cognitive and psychiatric problems. AIMS: To establish the nature and prevalence of psychiatric disorder and neurocognitive impairment in children with 22q11.2DS and test whether risk of psychopathology is mediated by the children's intellectual impairment. METHOD: Neurocognition and psychopathology were assessed in 80 children with 22q11.2DS (mean age 10.2 years, s.d. = 2.1) and 39 sibling controls (mean age 10.9 years, s.d. = 2.0). RESULTS: More than half (54 of children with 22q11.2DS met diagnostic criteria for one or more DSM-IV-TR psychiatric disorder. These children had lower IQ (mean 76.8, s.d. = 13.0) than controls (mean 108.6, s.d. = 15.2) (P

U2 - 10.1192/bjp.bp.113.132324

DO - 10.1192/bjp.bp.113.132324

M3 - Article (Academic Journal)

C2 - 24115343

SN - 0007-1250

VL - 204

SP - 46

EP - 54

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - 1

ER -

Psychopathology and cognition in children with 22q11.2 deletion syndrome

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