Pulmonary aerosol delivery and the importance of growth dynamics

Allen E. Haddrell, David Lewis, Tanya Church, Reinhard Vehring, Darragh Murnane, Jonathan P. Reid*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)
309 Downloads (Pure)

Abstract

Aerosols are dynamic systems, responding to variations in the surrounding environmental conditions by changing in size, composition and phase. Although widely used in inhalation therapies, details of the processes occurring on aerosol generation and during inhalation have received little attention. Instead, research has focussed on improvements to the formulation of the drug prior to aerosolisation and the resulting clinical efficacy of the treatment. Here, we highlight the processes that occur during aerosol generation and inhalation, affecting aerosol disposition when deposited and, potentially, impacting total and regional doses. In particular we examine the response of aerosol particles to the humid environment of the respiratory tract, considering both the capacity of particles to grow by absorbing moisture and the timescale for condensation to occur.
Original languageEnglish
Pages (from-to)1051-1061
Number of pages11
JournalTherapeutic Delivery
Volume8
Issue number12
Early online date10 Nov 2017
DOIs
Publication statusPublished - 1 Dec 2017

Keywords

  • aerosol microphysics
  • condensation
  • moisture
  • drug delivery to the lungs
  • inhalation

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