Pulmonary Protection Strategies in Cardiac Surgery: Are We Making Any Progress?

Emad Al Jaaly, Mustafa Zakkar, Francesca Fiorentino, Gianni D Angelini

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)


Pulmonary dysfunction is a common complication of cardiac surgery. The mechanisms involved in the development of pulmonary dysfunction are multifactorial and can be related to the activation of inflammatory and oxidative stress pathways. Clinical manifestation varies from mild atelectasis to severe respiratory failure. Managing pulmonary dysfunction postcardiac surgery is a multistep process that starts before surgery and continues during both the operative and postoperative phases. Different pulmonary protection strategies have evolved over the years; however, the wide acceptance and clinical application of such techniques remain hindered by the poor level of evidence or the sample size of the studies. A better understanding of available modalities and/or combinations can result in the development of customised strategies for the different cohorts of patients with the potential to hence maximise patients and institutes benefits.

Original languageEnglish
Pages (from-to)416235
JournalOxidative medicine and cellular longevity
Publication statusPublished - 2015

Structured keywords

  • Centre for Surgical Research


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