Pulsed electrolysis: enhancing primary benzylic C(sp 3 )–H nucleophilic fluorination

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)


Electrosynthesis is an efficient and powerful tool for the generation of elusive reactive intermediates. The application of alternative electrolysis waveforms provides a new level of control for dynamic redox environments. Herein, we demonstrate that pulsed electrolysis provides a favourable environment for the generation and fluorination of highly unstable primary benzylic cations from C(sp3)–H bonds. By introduction of a toff period, we propose this waveform modulates the electrical double layer to improve mass transport and limit over-oxidation.
Original languageEnglish
Pages (from-to)802-808
JournalOrganic Chemistry Frontiers
Publication statusPublished - 13 Dec 2023

Bibliographical note

Funding Information:
We would like to thank the Royal Society (University Research Fellowship and Enhancement awards to AJJL), the EPSRC (EP/S018 050/1), the European Research Council (949821, SENF) and Syngenta for generous funding.

Publisher Copyright:
© 2024 The Royal Society of Chemistry.


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