Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy) carbamates

Ian Hazelden; Rafaela Costa Carmona; Thomas Langer; Paul Pringle; John Bower

doi:10.1002/anie.201801109

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy) carbamates

Ian Hazelden, Rafaela Costa Carmona, Thomas Langer, Paul Pringle, John Bower

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

Original language	English
Pages (from-to)	5124-5128
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	18
Early online date	22 Mar 2018
DOIs	https://doi.org/10.1002/anie.201801109
Publication status	Published - 23 Apr 2018

Keywords

aza-Heck reaction
cascade reactions
N-heterocycles
palladium

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title = "Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy) carbamates",

abstract = "Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines. ",

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T1 - Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy) carbamates

AU - Hazelden, Ian

AU - Costa Carmona, Rafaela

AU - Langer, Thomas

AU - Pringle, Paul

AU - Bower, John

PY - 2018/4/23

Y1 - 2018/4/23

N2 - Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

AB - Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

KW - aza-Heck reaction

KW - cascade reactions

KW - N-heterocycles

KW - palladium

U2 - 10.1002/anie.201801109

DO - 10.1002/anie.201801109

M3 - Article (Academic Journal)

C2 - 29488677

SN - 1433-7851

VL - 57

SP - 5124

EP - 5128

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 18

ER -

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy) carbamates

Abstract

Keywords

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