Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy) carbamates

Ian Hazelden, Rafaela Costa Carmona, Thomas Langer, Paul Pringle, John Bower

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)
317 Downloads (Pure)

Abstract

Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.
Original languageEnglish
Pages (from-to)5124-5128
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number18
Early online date22 Mar 2018
DOIs
Publication statusPublished - 23 Apr 2018

Keywords

  • aza-Heck reaction
  • cascade reactions
  • N-heterocycles
  • palladium

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