Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies

Isabel Fortier; Paul R Burton; Paula J Robson; Vincent Ferretti; Julian Little; Francois L'Heureux; Mylène Deschênes; Bartha M Knoppers; Dany Doiron; Joost C Keers; Pamela Linksted; Jennifer R Harris; Geneviève Lachance; Catherine Boileau; Nancy L Pedersen; Carol M Hamilton; Kristian Hveem; Marilyn J Borugian; Richard P Gallagher; John McLaughlin; Louise Parker; John D Potter; John Gallacher; Rudolf Kaaks; Bette Liu; Tim Sprosen; Anne Vilain; Susan A Atkinson; Andrea Rengifo; Robin Morton; Andres Metspalu; H Erich Wichmann; Mark Tremblay; Rex L Chisholm; Andrés Garcia-Montero; Hans Hillege; Jan-Eric Litton; Lyle J Palmer; Markus Perola; Bruce H R Wolffenbuttel; Leena Peltonen; Thomas J Hudson

doi:10.1093/ije/dyq139

Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies

Isabel Fortier, Paul R Burton, Paula J Robson, Vincent Ferretti, Julian Little, Francois L'Heureux, Mylène Deschênes, Bartha M Knoppers, Dany Doiron, Joost C Keers, Pamela Linksted, Jennifer R Harris, Geneviève Lachance, Catherine Boileau, Nancy L Pedersen, Carol M Hamilton, Kristian Hveem, Marilyn J Borugian, Richard P Gallagher, John McLaughlinLouise Parker, John D Potter, John Gallacher, Rudolf Kaaks, Bette Liu, Tim Sprosen, Anne Vilain, Susan A Atkinson, Andrea Rengifo, Robin Morton, Andres Metspalu, H Erich Wichmann, Mark Tremblay, Rex L Chisholm, Andrés Garcia-Montero, Hans Hillege, Jan-Eric Litton, Lyle J Palmer, Markus Perola, Bruce H R Wolffenbuttel, Leena Peltonen, Thomas J Hudson

Research output: Contribution to journal › Article (Academic Journal) › peer-review

150 Citations (Scopus)

Abstract

Vast sample sizes are often essential in the quest to disentangle the complex interplay of the genetic, lifestyle, environmental and social factors that determine the aetiology and progression of chronic diseases. The pooling of information between studies is therefore of central importance to contemporary bioscience. However, there are many technical, ethico-legal and scientific challenges to be overcome if an effective, valid, pooled analysis is to be achieved. Perhaps most critically, any data that are to be analysed in this way must be adequately 'harmonized'. This implies that the collection and recording of information and data must be done in a manner that is sufficiently similar in the different studies to allow valid synthesis to take place.

Original language	English
Pages (from-to)	1383-93
Number of pages	11
Journal	International Journal of Epidemiology
Volume	39
Issue number	5
DOIs	https://doi.org/10.1093/ije/dyq139
Publication status	Published - Oct 2010

Keywords

Clinical Trials as Topic
Data Collection
Data Interpretation, Statistical
Epidemiologic Methods
Health Behavior
Humans
Information Storage and Retrieval
Meta-Analysis as Topic
Residence Characteristics
Socioeconomic Factors

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Fortier, I., Burton, P. R., Robson, P. J., Ferretti, V., Little, J., L'Heureux, F., Deschênes, M., Knoppers, B. M., Doiron, D., Keers, J. C., Linksted, P., Harris, J. R., Lachance, G., Boileau, C., Pedersen, N. L., Hamilton, C. M., Hveem, K., Borugian, M. J., Gallagher, R. P., ... Hudson, T. J. (2010). Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies. International Journal of Epidemiology, 39(5), 1383-93. https://doi.org/10.1093/ije/dyq139

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title = "Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies",

abstract = "Vast sample sizes are often essential in the quest to disentangle the complex interplay of the genetic, lifestyle, environmental and social factors that determine the aetiology and progression of chronic diseases. The pooling of information between studies is therefore of central importance to contemporary bioscience. However, there are many technical, ethico-legal and scientific challenges to be overcome if an effective, valid, pooled analysis is to be achieved. Perhaps most critically, any data that are to be analysed in this way must be adequately 'harmonized'. This implies that the collection and recording of information and data must be done in a manner that is sufficiently similar in the different studies to allow valid synthesis to take place.",

keywords = "Clinical Trials as Topic, Data Collection, Data Interpretation, Statistical, Epidemiologic Methods, Health Behavior, Humans, Information Storage and Retrieval, Meta-Analysis as Topic, Residence Characteristics, Socioeconomic Factors",

author = "Isabel Fortier and Burton, {Paul R} and Robson, {Paula J} and Vincent Ferretti and Julian Little and Francois L'Heureux and Myl{\`e}ne Desch{\^e}nes and Knoppers, {Bartha M} and Dany Doiron and Keers, {Joost C} and Pamela Linksted and Harris, {Jennifer R} and Genevi{\`e}ve Lachance and Catherine Boileau and Pedersen, {Nancy L} and Hamilton, {Carol M} and Kristian Hveem and Borugian, {Marilyn J} and Gallagher, {Richard P} and John McLaughlin and Louise Parker and Potter, {John D} and John Gallacher and Rudolf Kaaks and Bette Liu and Tim Sprosen and Anne Vilain and Atkinson, {Susan A} and Andrea Rengifo and Robin Morton and Andres Metspalu and Wichmann, {H Erich} and Mark Tremblay and Chisholm, {Rex L} and Andr{\'e}s Garcia-Montero and Hans Hillege and Jan-Eric Litton and Palmer, {Lyle J} and Markus Perola and Wolffenbuttel, {Bruce H R} and Leena Peltonen and Hudson, {Thomas J}",

year = "2010",

month = oct,

doi = "10.1093/ije/dyq139",

language = "English",

volume = "39",

pages = "1383--93",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

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Fortier, I, Burton, PR, Robson, PJ, Ferretti, V, Little, J, L'Heureux, F, Deschênes, M, Knoppers, BM, Doiron, D, Keers, JC, Linksted, P, Harris, JR, Lachance, G, Boileau, C, Pedersen, NL, Hamilton, CM, Hveem, K, Borugian, MJ, Gallagher, RP, McLaughlin, J, Parker, L, Potter, JD, Gallacher, J, Kaaks, R, Liu, B, Sprosen, T, Vilain, A, Atkinson, SA, Rengifo, A, Morton, R, Metspalu, A, Wichmann, HE, Tremblay, M, Chisholm, RL, Garcia-Montero, A, Hillege, H, Litton, J-E, Palmer, LJ, Perola, M, Wolffenbuttel, BHR, Peltonen, L & Hudson, TJ 2010, 'Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies', International Journal of Epidemiology, vol. 39, no. 5, pp. 1383-93. https://doi.org/10.1093/ije/dyq139

TY - JOUR

T1 - Quality, quantity and harmony

T2 - the DataSHaPER approach to integrating data across bioclinical studies

AU - Fortier, Isabel

AU - Burton, Paul R

AU - Robson, Paula J

AU - Ferretti, Vincent

AU - Little, Julian

AU - L'Heureux, Francois

AU - Deschênes, Mylène

AU - Knoppers, Bartha M

AU - Doiron, Dany

AU - Keers, Joost C

AU - Linksted, Pamela

AU - Harris, Jennifer R

AU - Lachance, Geneviève

AU - Boileau, Catherine

AU - Pedersen, Nancy L

AU - Hamilton, Carol M

AU - Hveem, Kristian

AU - Borugian, Marilyn J

AU - Gallagher, Richard P

AU - McLaughlin, John

AU - Parker, Louise

AU - Potter, John D

AU - Gallacher, John

AU - Kaaks, Rudolf

AU - Liu, Bette

AU - Sprosen, Tim

AU - Vilain, Anne

AU - Atkinson, Susan A

AU - Rengifo, Andrea

AU - Morton, Robin

AU - Metspalu, Andres

AU - Wichmann, H Erich

AU - Tremblay, Mark

AU - Chisholm, Rex L

AU - Garcia-Montero, Andrés

AU - Hillege, Hans

AU - Litton, Jan-Eric

AU - Palmer, Lyle J

AU - Perola, Markus

AU - Wolffenbuttel, Bruce H R

AU - Peltonen, Leena

AU - Hudson, Thomas J

PY - 2010/10

Y1 - 2010/10

N2 - Vast sample sizes are often essential in the quest to disentangle the complex interplay of the genetic, lifestyle, environmental and social factors that determine the aetiology and progression of chronic diseases. The pooling of information between studies is therefore of central importance to contemporary bioscience. However, there are many technical, ethico-legal and scientific challenges to be overcome if an effective, valid, pooled analysis is to be achieved. Perhaps most critically, any data that are to be analysed in this way must be adequately 'harmonized'. This implies that the collection and recording of information and data must be done in a manner that is sufficiently similar in the different studies to allow valid synthesis to take place.

AB - Vast sample sizes are often essential in the quest to disentangle the complex interplay of the genetic, lifestyle, environmental and social factors that determine the aetiology and progression of chronic diseases. The pooling of information between studies is therefore of central importance to contemporary bioscience. However, there are many technical, ethico-legal and scientific challenges to be overcome if an effective, valid, pooled analysis is to be achieved. Perhaps most critically, any data that are to be analysed in this way must be adequately 'harmonized'. This implies that the collection and recording of information and data must be done in a manner that is sufficiently similar in the different studies to allow valid synthesis to take place.

KW - Clinical Trials as Topic

KW - Data Collection

KW - Data Interpretation, Statistical

KW - Epidemiologic Methods

KW - Health Behavior

KW - Humans

KW - Information Storage and Retrieval

KW - Meta-Analysis as Topic

KW - Residence Characteristics

KW - Socioeconomic Factors

U2 - 10.1093/ije/dyq139

DO - 10.1093/ije/dyq139

M3 - Article (Academic Journal)

C2 - 20813861

SN - 0300-5771

VL - 39

SP - 1383

EP - 1393

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 5

ER -

Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies

Abstract

Keywords

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