Quantifying changes in gap junction structure as a function of lens fiber cell differentiation. Cell communication & adhesion

M D Jacobs, C Soeller, M B Cannell, P J Donaldson

Research output: Contribution to journalArticle (Academic Journal)

Abstract

The ocular lens is an ideal model system for studying gap junction structure-function relationships. Here we apply novel methods to quantitatively compare connexin expression over macroscopic distances while simultaneously resolving the intracellular distribution of gap junctions in sub-micron detail. Our approach has identified three distinct zones of connexin density and allowed changes in gap junction plaque size, number and dispersion to be quantified. Our analysis is the first to precisely correlate changes in gap junction plaque structure with the reported changes in gap junction function that occur as a consequence of fiber cell differentiation.
Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalCell Communication and Adhesion
Volume8
Issue number4-6
Publication statusPublished - 1 Jan 2001

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