Quantifying end-to-end conformational communication of chirality through an achiral peptide chain

Jonathan Clayden*, Alejandro Castellanos, Jordi Solà, Gareth A. Morris

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

81 Citations (Scopus)

Abstract

Successful communication: Two diastereotopic protons more than 60 bonds from the nearest chiral center appear as an AB system, showing that the intervening structure is a well-ordered helix. Decay of anisochronicity quantifies the linear persistence of a helix of achiral amino acids: as little as 3.5 % of the chiral influence is lost with each additional achiral residue.

Original languageEnglish
Pages (from-to)5962-5965
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number32
Early online date30 Jun 2009
DOIs
Publication statusPublished - 27 Jul 2009

Keywords

  • Anisochronicity
  • Conformation analysis
  • Helicity
  • NMR spectroscopy
  • Peptides

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