Abstract
Long lasting insecticidal nets (LLINs) provide both direct and indirect protection against malaria. As pyrethroid resistance evolves in mosquito vectors, it will be useful to understand how the specific benefits LLINs afford individuals and communities may be affected. Here we use modelling to show that there is no minimum LLIN usage needed for users and non-users to benefit from community protection. Modelling results also indicate that pyrethroid resistance in local mosquitoes will likely diminish the direct and indirect benefits from insecticides, leaving the barrier effects intact, but LLINs are still expected to provide enhanced benefit over untreated nets even at high levels of pyrethroid resistance.
| Original language | English |
|---|---|
| Article number | 676 |
| Journal | Nature Communications |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 8 Feb 2023 |
Bibliographical note
Funding Information:H.J.T.U. and A.C.G. were funded by a grant from the Bill and Melinda Gates foundation, and HTU additionally from an Imperial College Research Fellowship. E.S.-S. is funded by a UKRI Future Leaders Fellowship from the Medical Research Council (MR/T041986/1). Funding support for T.S.C. and E.S.-S. was also received from the Innovative Vector Control Consortium through the New Nets Project funded by Unitaid, the Wellcome Trust [200222/Z/15/Z] MiRA. All authors acknowledge funding from the MRC Centre for Global Infectious Disease Analysis (reference MR/R015600/1), jointly funded by the UK Medical Research Council (MRC) and the UK Foreign, Commonwealth & Development Office (FCDO), under the MRC/FCDO Concordat agreement and is also part of the EDCTP2 programme supported by the European Union.
Publisher Copyright:
© 2023, The Author(s).
