Quantifying the role of stochasticity in the development of autoimmune disease

Lindsay B Nicholson*, Konstantin Blyuss*, Farzad Fatehi

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

36 Downloads (Pure)

Abstract

In this paper we propose and analyse a mathematical model for the onset and development of autoimmune disease, with particular attention to stochastic effects in the dynamics. Stability analysis yields parameter regions associated with normal cell homeostasis, or sustained periodic oscillations. Variance of these oscillations and the effects of stochastic amplification are also explored. Theoretical results are complemented by experiments, in which experimental autoimmune uveoretinitis (EAU) was induced in B10.RIII and C57BL/6 mice. For both cases, we discuss peculiarities of disease development, the levels of variation in T cell populations in a population of genetically identical organisms, as well as a comparison with model outputs.
Original languageEnglish
Article number860
Number of pages23
JournalCells
Volume9
Issue number4
DOIs
Publication statusPublished - 2 Apr 2020

Keywords

  • Mathematical model
  • Immune response
  • Autoimmunity
  • Stochasticity

Fingerprint Dive into the research topics of 'Quantifying the role of stochasticity in the development of autoimmune disease'. Together they form a unique fingerprint.

  • Cite this