Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study.

B.M. Davies, S. Rikabi, A. French, R. Pinedo-Villanueva, M.E. Morrey, K. Wartolowska, A. Judge, R.E. MacLaren, A. Mathur, D.J. Williams, I. Wall, M. Birchall, B. Reeve, A. Atala, R.W. Barker, Z. Cui, D. Furniss, K. Bure, E.Y. Snyder, J.M. KarpA. Price, A. Carr, D.A. Brindley

Research output: Contribution to journalArticle (Academic Journal)

Abstract

There has been a large increase in basic science activity in cell therapy and a growing portfolio of cell therapy trials. However, the number of industry products available for widespread clinical use does not match this magnitude of activity. We hypothesize that the paucity of engagement with the clinical community is a key contributor to the lack of commercially successful cell therapy products. To investigate this, we launched a pilot study to survey clinicians from five specialities and to determine what they believe to be the most significant barriers to cellular therapy clinical development and adoption. Our study shows that the main concerns among this group are cost-effectiveness, efficacy, reimbursement, and regulation. Addressing these concerns can best be achieved by ensuring that future clinical trials are conducted to adequately answer the questions of both regulators and the broader clinical community.
Original languageEnglish
Pages (from-to)2041731414551764
JournalJournal of Tissue Engineering
Volume5
DOIs
Publication statusPublished - Jan 2014

Bibliographical note

M1 - Electronic-eCollection

Fingerprint Dive into the research topics of 'Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study.'. Together they form a unique fingerprint.

  • Cite this

    Davies, B. M., Rikabi, S., French, A., Pinedo-Villanueva, R., Morrey, M. E., Wartolowska, K., Judge, A., MacLaren, R. E., Mathur, A., Williams, D. J., Wall, I., Birchall, M., Reeve, B., Atala, A., Barker, R. W., Cui, Z., Furniss, D., Bure, K., Snyder, E. Y., ... Brindley, D. A. (2014). Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study. Journal of Tissue Engineering, 5, 2041731414551764. https://doi.org/10.1177/2041731414551764