Quantitative imaging of arsenic and its species in goat following long term oral exposure

Pabitra Hriday Patra, Samiran Bandyopadhyay, Rakesh Kumar, Bakul Kumar Datta, Chinmoy Maji, Suman Biswas, Jeevan Ranjan Dash, Tapas Kumar Sar, Samar Sarkar, Sanjib K Manna, Animesh Kumar Chakraborty, Tapan Kumar Mandal

Research output: Contribution to journalArticle (Academic Journal)peer-review


Severity of arsenic toxicity was reported to vary depending on its species. The present study reflects the status of different species of arsenic in goat following long-term exposure of arsenic leading to hepatic damage. The experiment was conducted with six black Bengal goats, which were administered with sodium arsenite orally at a dose rate of 2 mgkg(-1) daily for 84 days. Faeces, urine, hair and blood samples were collected from those animals at 14 days interval. Excretion of total arsenic was reduced from 56 days onwards through both faeces and urine indicating higher accumulation of arsenic in body. The speciation study revealed that urinary arsenic was mainly of organic type, whereas hair accumulated almost equal proportion of arsenite, arsenate and organo arsenicals. Goats excreted high proportion of organo arsenicals through faeces possibly due to hepatobiliary secretion of organo arsenic into the gut. Significantly elevated serum alanine aminotransferase and aspartate aminotransferase activities (p<0.05) along with histopathological changes in liver indicated hepatotoxicity. The arsenite fraction increased and organic proportion decreased in urine as the time progressed, which indicates that arsenite gets methylated in liver of goat. The study thus alluded that the toxicity of arsenic would aggravate if the animals were exposed for long time as the hepatotoxicity progressed resulting in decreased methylation and formation of organo arsenicals and decreased excretions through urine.

Original languageEnglish
Pages (from-to)1946-50
Number of pages5
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Issue number6
Publication statusPublished - Jun 2012

Bibliographical note

Copyright © 2012 Elsevier Ltd. All rights reserved.


  • Administration, Oral
  • Alanine Transaminase/blood
  • Animals
  • Arsenates/chemistry
  • Arsenic/chemistry
  • Arsenites/chemistry
  • Aspartate Aminotransferases/blood
  • Calibration
  • Fatty Liver/chemically induced
  • Female
  • Goats
  • Liver/pathology
  • Reproducibility of Results

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