The practical synthesis of novel multivalent fluorescent Quantum Dot (QD)-based probes to target cellular matrix metalloproteinases (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.
|Publication status||Accepted/In press - 21 Jun 2018|
Benito-Alifonso, D., Richichi, B., Baldoneschi, V., Berry, M., Fragai, M., Salerno, G., Galan, C., & Nativi, C. (Accepted/In press). Quantum dot-based probes for labeling and imaging of cells that express matrix metalloproteinases (MT-MMPs). ACS Omega.