Quantum dot-based probes for labeling and imaging of cells that express matrix metalloproteinases (MT-MMPs)

David Benito-Alifonso, Barbara Richichi, Veronica Baldoneschi, Monica Berry, Marco Fragai, Gianluca Salerno, Carmen Galan, Cristina Nativi

Research output: Contribution to journalArticle (Academic Journal)

Abstract

The practical synthesis of novel multivalent fluorescent Quantum Dot (QD)-based probes to target cellular matrix metalloproteinases (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.
Original languageEnglish
JournalACS Omega
Publication statusAccepted/In press - 21 Jun 2018

Fingerprint Dive into the research topics of 'Quantum dot-based probes for labeling and imaging of cells that express matrix metalloproteinases (MT-MMPs)'. Together they form a unique fingerprint.

  • Cite this

    Benito-Alifonso, D., Richichi, B., Baldoneschi, V., Berry, M., Fragai, M., Salerno, G., Galan, C., & Nativi, C. (Accepted/In press). Quantum dot-based probes for labeling and imaging of cells that express matrix metalloproteinases (MT-MMPs). ACS Omega.