Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity

Thangavel Thirunavukkarasu, Hazel A. Sparkes, Karuppannan Natarajan*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)
177 Downloads (Pure)

Abstract

Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.

Original languageEnglish
Pages (from-to)229-239
Number of pages11
JournalInorganica Chimica Acta
Volume482
Early online date4 Jun 2018
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Quinoline
  • Palladium(II) complex
  • DNA/protein binding
  • Cytotoxicity

Fingerprint Dive into the research topics of 'Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity'. Together they form a unique fingerprint.

Cite this