TY - JOUR
T1 - Quinoline based Pd(II) complexes
T2 - Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity
AU - Thirunavukkarasu, Thangavel
AU - Sparkes, Hazel A.
AU - Natarajan, Karuppannan
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.
AB - Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.
KW - Quinoline
KW - Palladium(II) complex
KW - DNA/protein binding
KW - Cytotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85048715683&partnerID=8YFLogxK
U2 - 10.1016/j.ica.2018.06.003
DO - 10.1016/j.ica.2018.06.003
M3 - Article (Academic Journal)
AN - SCOPUS:85048715683
VL - 482
SP - 229
EP - 239
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
SN - 0020-1693
ER -