Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity

Thangavel Thirunavukkarasu; Hazel A. Sparkes; Karuppannan Natarajan

doi:10.1016/j.ica.2018.06.003

Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity

Thangavel Thirunavukkarasu, Hazel A. Sparkes, Karuppannan Natarajan^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.

Original language	English
Pages (from-to)	229-239
Number of pages	11
Journal	Inorganica Chimica Acta
Volume	482
Early online date	4 Jun 2018
DOIs	https://doi.org/10.1016/j.ica.2018.06.003
Publication status	Published - 1 Oct 2018

Keywords

Quinoline
Palladium(II) complex
DNA/protein binding
Cytotoxicity

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10.1016/j.ica.2018.06.003

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title = "Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity",

abstract = "Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.",

keywords = "Quinoline, Palladium(II) complex, DNA/protein binding, Cytotoxicity",

author = "Thangavel Thirunavukkarasu and Sparkes, {Hazel A.} and Karuppannan Natarajan",

year = "2018",

month = oct,

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doi = "10.1016/j.ica.2018.06.003",

language = "English",

volume = "482",

pages = "229--239",

journal = "Inorganica Chimica Acta",

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Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity. / Thirunavukkarasu, Thangavel; Sparkes, Hazel A.; Natarajan, Karuppannan.
In: Inorganica Chimica Acta, Vol. 482, 01.10.2018, p. 229-239.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Quinoline based Pd(II) complexes

T2 - Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity

AU - Thirunavukkarasu, Thangavel

AU - Sparkes, Hazel A.

AU - Natarajan, Karuppannan

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.

AB - Two new palladium(II) complexes from 2-methyl 4-amino quinoline were synthesized and characterized by analytical, spectroscopic and X-ray diffraction techniques. The binding affinity and binding mode of the ligand and mononuclear complexes toward CT-DNA/BSA were determined by spectrophotometric titrations. From the binding studies, it has been found that the complexes interact strongly with CT-DNA and BSA. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines indicted better cytotoxic effect.

KW - Quinoline

KW - Palladium(II) complex

KW - DNA/protein binding

KW - Cytotoxicity

UR - http://www.scopus.com/inward/record.url?scp=85048715683&partnerID=8YFLogxK

U2 - 10.1016/j.ica.2018.06.003

DO - 10.1016/j.ica.2018.06.003

M3 - Article (Academic Journal)

AN - SCOPUS:85048715683

SN - 0020-1693

VL - 482

SP - 229

EP - 239

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Quinoline based Pd(II) complexes: Synthesis, characterization and evaluation of DNA/protein binding, molecular docking and in vitro anticancer activity

Abstract

Keywords

UN SDGs

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