Random-coil: α-helix equilibria as a reporter for the Lewis X-Lewis X interaction

Timothy M. Altamore; Christian Fernández-García; Andrew H. Gordon; Tina Hübscher; Netnapa Promsawan; Maxim G. Ryadnov; Andrew J. Doig; Derek N. Woolfson; Timothy Gallagher

doi:10.1002/anie.201101055

Random-coil: α-helix equilibria as a reporter for the Lewis ^X-Lewis ^X interaction

Timothy M. Altamore, Christian Fernández-García, Andrew H. Gordon, Tina Hübscher, Netnapa Promsawan, Maxim G. Ryadnov, Andrew J. Doig, Derek N. Woolfson^*, Timothy Gallagher

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

14 Citations (Scopus)

Abstract

Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate-carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis ^X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation.

Original language	English
Pages (from-to)	11167-11171
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	47
DOIs	https://doi.org/10.1002/anie.201101055
Publication status	Published - 18 Nov 2011

Keywords

carbohydrate-carbohydrate interaction
Lewis
peptide reporter

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title = "Random-coil: α-helix equilibria as a reporter for the Lewis X-Lewis X interaction",

abstract = "Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate-carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation.",

keywords = "carbohydrate-carbohydrate interaction, Lewis, peptide reporter",

author = "Altamore, {Timothy M.} and Christian Fern{\'a}ndez-Garc{\'i}a and Gordon, {Andrew H.} and Tina H{\"u}bscher and Netnapa Promsawan and Ryadnov, {Maxim G.} and Doig, {Andrew J.} and Woolfson, {Derek N.} and Timothy Gallagher",

year = "2011",

month = nov,

day = "18",

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journal = "Angewandte Chemie - International Edition",

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T2 - α-helix equilibria as a reporter for the Lewis X-Lewis X interaction

AU - Altamore, Timothy M.

AU - Fernández-García, Christian

AU - Gordon, Andrew H.

AU - Hübscher, Tina

AU - Promsawan, Netnapa

AU - Ryadnov, Maxim G.

AU - Doig, Andrew J.

AU - Woolfson, Derek N.

AU - Gallagher, Timothy

PY - 2011/11/18

Y1 - 2011/11/18

N2 - Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate-carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation.

AB - Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate-carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation.

KW - carbohydrate-carbohydrate interaction

KW - Lewis

KW - peptide reporter

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U2 - 10.1002/anie.201101055

DO - 10.1002/anie.201101055

M3 - Article (Academic Journal)

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AN - SCOPUS:81255162978

SN - 1433-7851

VL - 50

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 47

ER -

Random-coil: α-helix equilibria as a reporter for the Lewis ^X-Lewis ^X interaction

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ELUCIDATING THE MOLECULAR BASIS OF CARBOHYDRATE-CARBOHYDRATE INTERACTION

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Random-coil: α-helix equilibria as a reporter for the Lewis X-Lewis X interaction

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ELUCIDATING THE MOLECULAR BASIS OF CARBOHYDRATE-CARBOHYDRATE INTERACTION

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Random-coil: α-helix equilibria as a reporter for the Lewis ^X-Lewis ^X interaction