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Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate-carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation.
- carbohydrate-carbohydrate interaction
- peptide reporter