Random-coil: α-helix equilibria as a reporter for the Lewis X-Lewis X interaction

Timothy M. Altamore, Christian Fernández-García, Andrew H. Gordon, Tina Hübscher, Netnapa Promsawan, Maxim G. Ryadnov, Andrew J. Doig, Derek N. Woolfson*, Timothy Gallagher

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)


Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate-carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation.

Original languageEnglish
Pages (from-to)11167-11171
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number47
Publication statusPublished - 18 Nov 2011


  • carbohydrate-carbohydrate interaction
  • Lewis
  • peptide reporter

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