Vaginal administration of the nitric oxide donor isosorbide mononitrate can induce effective ripening of the human cervix. We investigated whether this drug is associated with fewer side-effects than prostaglandins when used to ripen the cervix before first-trimester surgical termination of pregnancy, and assessed whether the extent of cervical ripening it induces is clinically sufficient.
Bibliographical noteRIS file
Thomson, A. J., Lunan, C. B., Ledingham, M., Howat, R. C., Cameron, I. T., Greer, I. A., & Norman, J. E. (1998). Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy. The Lancet, 352(9134), 1093-1096. https://doi.org/10.1016/S0140-6736(98)01289-6