Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy

A. J. Thomson, C. B. Lunan, M. Ledingham, R. C. Howat, I. T. Cameron, I. A. Greer, J. E. Norman

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Vaginal administration of the nitric oxide donor isosorbide mononitrate can induce effective ripening of the human cervix. We investigated whether this drug is associated with fewer side-effects than prostaglandins when used to ripen the cervix before first-trimester surgical termination of pregnancy, and assessed whether the extent of cervical ripening it induces is clinically sufficient.
Original languageEnglish
Pages (from-to)1093-1096
Number of pages4
JournalThe Lancet
Volume352
Issue number9134
DOIs
Publication statusPublished - 1998

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