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Randomized clinical trial to determine if changes in dentine tubule occlusion visualized by SEM of replica impressions correlate with pain scores: in vivo assessment of tubule occlusion

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalAmerican Journal of Dentistry
DateAccepted/In press - 9 Mar 2018
DatePublished (current) - 1 Aug 2018


Purpose: To quantify dentine tubule occlusion and correlate this with pain reduction in vivo. Methods: This was a single-center, randomized two treatment, examiner-blind, parallel study. 20 participants with confirmed dentine hypersensitivity (DH) were evaluated by Schiff Air Blast, VAS Air Blast and replica impression of the tooth surface to visualize tubule occlusion at baseline and following 4 week twice daily use of either an occluding toothpaste (8% strontium acetate, 1040 ppm fluoride) or a non-occluding toothpaste (1450ppm fluoride). Results: Both treatments increased tubule occlusion significantly from baseline to 4 weeks (p = 0.01) with significant decreases in pain score only seen with the occluding toothpaste (Schiff, p = 0.01; VAS, p = 0.01). Schiff pain score after 4 weeks was markedly reduced following treatment with the occluding toothpaste as compared to the non-occluding toothpaste, (p = 0.05) with no significant differences between the pastes for occlusion score or patient reported VAS, although the scores favored the occluding toothpaste.
Clinical Significance: Occlusion scores as obtained by replica impression techniques with SEM imaging correlate significantly with DH pain scores confirming proof of concept. With further refinement, this technique could be used to accurately quantify tubule occlusion in vivo and the associated pain reduction achieved by occluding toothpastes.

    Research areas

  • dentine hypersensitivity, replica impression, occlusion, pain

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    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available via American Journal of Dentistry . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 194 KB, PDF document


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