Randomized in situ clinical study comparing the ability of two new desensitizing toothpaste technologies to occlude patent dentin tubules

N X West, E L Macdonald, S B Jones, N C A Claydon, N Hughes, P Jeffery

Research output: Contribution to journalArticle (Academic Journal)peer-review

29 Citations (Scopus)


OBJECTIVE: To compare the ability of two new desensitizing toothpaste technologies (one a 5% NovaMin-based toothpaste and the other an 8% arginine-based toothpaste) to occlude patent dentin tubules in a clinical environment relative to a negative control of water and a control toothpaste after four days of twice-daily brushing and dietary acidic challenges.

METHODS: The study design was a single-center, single-blind, randomized, split-mouth, four-treatment, two-period, crossover, in situ clinical study. Healthy subjects wore two lower intra-oral appliances, retaining four dentin samples for four treatment days for each period of the clinical study. Samples were brushed twice daily with a test product (days 1-4), with an additional acidic challenge introduced on two selective days. Scanning electron microscopy (SEM) images were taken of the dentin surface, and dentinal tubule occlusion assessed using a categorical scale.

RESULTS: The results demonstrated that the 5% NovaMin toothpaste was statistically superior at occluding patent dentin tubules compared to water (p = 0.009) and the control toothpaste (p = 0.02) at day 4. In contrast, the treatment effect resulting from the 8% arginine toothpaste did not demonstrate the same degree of occlusive propensity, showing no significant difference to the water and control toothpaste at the day 4 time point.

CONCLUSION: Application of the 5% NovaMin toothpaste to dentin showed better dentin tubule occlusion and retention abilities in an oral environment under dietary acid challenge conditions, more so than the 8% arginine toothpaste technology. Given modern dietary habits and practices, these results highlight differences in the acid resistance properties of occlusion technologies, and a potential impact on clinical performance.
Original languageEnglish
Pages (from-to)82 - 89
Number of pages8
JournalJournal of Clinical Dentistry
Issue number3
Publication statusPublished - 2011


  • Acids
  • Adult
  • Arginine
  • Beverages
  • Calcium Carbonate
  • Citrus paradisi
  • Cross-Over Studies
  • Dentin
  • Dentin Desensitizing Agents
  • Female
  • Fluorides
  • Glass
  • Humans
  • Male
  • Microscopy, Electron, Scanning
  • Phosphates
  • Single-Blind Method
  • Time Factors
  • Toothpastes
  • Water

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