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Randomized In Situ Clinical Trial Evaluating Erosion Protection Efficacy of a 0.454% Stannous Fluoride Dentifrice: Erosion protection from SnF2 dentifrice

Research output: Contribution to journalArticle

Original languageEnglish
Number of pages7
JournalInternational Journal of Dental Hygiene
Early online date19 Feb 2019
DateAccepted/In press - 16 Dec 2018
DateE-pub ahead of print (current) - 19 Feb 2019


Objectives: To assess the protective effects of a 0.454% stabilized stannous fluoride dentifrice and a marketed triclosan dentifrice against enamel erosion in a 10-day in situ model. Methods: This was a double-blind, randomized, 2-treatment, 4-period, crossover in situ trial involving healthy adult participants. Participants were randomized to a treatment sequence involving the following products: a highly bioavailable 0.454% stannous fluoride dentifrice (Procter & Gamble) and a marketed dentifrice control containing 0.24% sodium fluoride and 0.3% triclosan (Colgate-Palmolive). Each study period took place over 10 days. Participants wore an intra-oral appliance retaining two polished human enamel samples for 6 hours per day. Two times per day they swished with the assigned dentifrice slurry and four times per day they swished with 250 mL of orange juice (25 mL per minute) over a 10-minute period. Contact profilometry measurements were made for each sample at baseline and day 10 to determine surface change. Results: Thirty-six participants were enrolled and 33 completed the study (mean age = 40.5 years). The stannous fluoride dentifrice demonstrated 93.5% less enamel loss than the NaF/triclosan dentifrice (P < 0.001) at Day 10, with median enamel loss of 0.097 µm and 1.495 µm, respectively. Both products were well tolerated. Conclusion: The stannous fluoride dentifrice demonstrated significantly greater erosion protection efficacy relative to the NaF/triclosan dentifrice in this randomized in situ clinical trial.

    Research areas

  • clinical trial, stannous fluoride, dental erosion, oral hygiene, dentifrice

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