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Randomized In Situ Clinical Trial Evaluating Erosion Protection Efficacy of a 0.454% Stannous Fluoride Dentifrice: Erosion protection from SnF2 dentifrice

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Randomized In Situ Clinical Trial Evaluating Erosion Protection Efficacy of a 0.454% Stannous Fluoride Dentifrice : Erosion protection from SnF2 dentifrice. / West, Nicola; He, Tao; Hellin, Nicola; Claydon, Nicholas; Seong, Joon; Macdonald, Emma; Farrell, Svetlana; Eusebio, Rachelle; Willberg, Aneta.

In: International Journal of Dental Hygiene, 19.02.2019.

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@article{b689876ce6364c959d40a0228af63035,
title = "Randomized In Situ Clinical Trial Evaluating Erosion Protection Efficacy of a 0.454{\%} Stannous Fluoride Dentifrice: Erosion protection from SnF2 dentifrice",
abstract = "Objectives: To assess the protective effects of a 0.454{\%} stabilized stannous fluoride dentifrice and a marketed triclosan dentifrice against enamel erosion in a 10-day in situ model. Methods: This was a double-blind, randomized, 2-treatment, 4-period, crossover in situ trial involving healthy adult participants. Participants were randomized to a treatment sequence involving the following products: a highly bioavailable 0.454{\%} stannous fluoride dentifrice (Procter & Gamble) and a marketed dentifrice control containing 0.24{\%} sodium fluoride and 0.3{\%} triclosan (Colgate-Palmolive). Each study period took place over 10 days. Participants wore an intra-oral appliance retaining two polished human enamel samples for 6 hours per day. Two times per day they swished with the assigned dentifrice slurry and four times per day they swished with 250 mL of orange juice (25 mL per minute) over a 10-minute period. Contact profilometry measurements were made for each sample at baseline and day 10 to determine surface change. Results: Thirty-six participants were enrolled and 33 completed the study (mean age = 40.5 years). The stannous fluoride dentifrice demonstrated 93.5{\%} less enamel loss than the NaF/triclosan dentifrice (P < 0.001) at Day 10, with median enamel loss of 0.097 µm and 1.495 µm, respectively. Both products were well tolerated. Conclusion: The stannous fluoride dentifrice demonstrated significantly greater erosion protection efficacy relative to the NaF/triclosan dentifrice in this randomized in situ clinical trial.",
keywords = "clinical trial, stannous fluoride, dental erosion, oral hygiene, dentifrice",
author = "Nicola West and Tao He and Nicola Hellin and Nicholas Claydon and Joon Seong and Emma Macdonald and Svetlana Farrell and Rachelle Eusebio and Aneta Willberg",
year = "2019",
month = "2",
day = "19",
doi = "10.1111/idh.12379",
language = "English",
journal = "International Journal of Dental Hygiene",
issn = "1601-5029",
publisher = "John Wiley & Sons, Ltd.",

}

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TY - JOUR

T1 - Randomized In Situ Clinical Trial Evaluating Erosion Protection Efficacy of a 0.454% Stannous Fluoride Dentifrice

T2 - Erosion protection from SnF2 dentifrice

AU - West, Nicola

AU - He, Tao

AU - Hellin, Nicola

AU - Claydon, Nicholas

AU - Seong, Joon

AU - Macdonald, Emma

AU - Farrell, Svetlana

AU - Eusebio, Rachelle

AU - Willberg, Aneta

PY - 2019/2/19

Y1 - 2019/2/19

N2 - Objectives: To assess the protective effects of a 0.454% stabilized stannous fluoride dentifrice and a marketed triclosan dentifrice against enamel erosion in a 10-day in situ model. Methods: This was a double-blind, randomized, 2-treatment, 4-period, crossover in situ trial involving healthy adult participants. Participants were randomized to a treatment sequence involving the following products: a highly bioavailable 0.454% stannous fluoride dentifrice (Procter & Gamble) and a marketed dentifrice control containing 0.24% sodium fluoride and 0.3% triclosan (Colgate-Palmolive). Each study period took place over 10 days. Participants wore an intra-oral appliance retaining two polished human enamel samples for 6 hours per day. Two times per day they swished with the assigned dentifrice slurry and four times per day they swished with 250 mL of orange juice (25 mL per minute) over a 10-minute period. Contact profilometry measurements were made for each sample at baseline and day 10 to determine surface change. Results: Thirty-six participants were enrolled and 33 completed the study (mean age = 40.5 years). The stannous fluoride dentifrice demonstrated 93.5% less enamel loss than the NaF/triclosan dentifrice (P < 0.001) at Day 10, with median enamel loss of 0.097 µm and 1.495 µm, respectively. Both products were well tolerated. Conclusion: The stannous fluoride dentifrice demonstrated significantly greater erosion protection efficacy relative to the NaF/triclosan dentifrice in this randomized in situ clinical trial.

AB - Objectives: To assess the protective effects of a 0.454% stabilized stannous fluoride dentifrice and a marketed triclosan dentifrice against enamel erosion in a 10-day in situ model. Methods: This was a double-blind, randomized, 2-treatment, 4-period, crossover in situ trial involving healthy adult participants. Participants were randomized to a treatment sequence involving the following products: a highly bioavailable 0.454% stannous fluoride dentifrice (Procter & Gamble) and a marketed dentifrice control containing 0.24% sodium fluoride and 0.3% triclosan (Colgate-Palmolive). Each study period took place over 10 days. Participants wore an intra-oral appliance retaining two polished human enamel samples for 6 hours per day. Two times per day they swished with the assigned dentifrice slurry and four times per day they swished with 250 mL of orange juice (25 mL per minute) over a 10-minute period. Contact profilometry measurements were made for each sample at baseline and day 10 to determine surface change. Results: Thirty-six participants were enrolled and 33 completed the study (mean age = 40.5 years). The stannous fluoride dentifrice demonstrated 93.5% less enamel loss than the NaF/triclosan dentifrice (P < 0.001) at Day 10, with median enamel loss of 0.097 µm and 1.495 µm, respectively. Both products were well tolerated. Conclusion: The stannous fluoride dentifrice demonstrated significantly greater erosion protection efficacy relative to the NaF/triclosan dentifrice in this randomized in situ clinical trial.

KW - clinical trial

KW - stannous fluoride

KW - dental erosion

KW - oral hygiene

KW - dentifrice

UR - http://www.scopus.com/inward/record.url?scp=85061907988&partnerID=8YFLogxK

U2 - 10.1111/idh.12379

DO - 10.1111/idh.12379

M3 - Article

JO - International Journal of Dental Hygiene

JF - International Journal of Dental Hygiene

SN - 1601-5029

ER -