Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years

Andrew Whitelaw, Sally Jary, Grazyna Kmita, Jolanta Wroblewska, Ewa Musialik-Swietlinska, Marek Mandera, Linda Hunt, Michael Carter, Ian Pople

Research output: Contribution to journalArticle (Academic Journal)peer-review

100 Citations (Scopus)

Abstract

Preterm infants who develop posthemorrhagic ventricular dilatation (PHVD) have a high risk of cognitive and motor disability. No clinical intervention has been proven to reduce neurodevelopmental disability in such infants. We investigated whether drainage, irrigation, and fibrinolytic therapy (DRIFT), which aims to lower pressure, distortion, free iron, and cytokines, reduces death or severe disability in PHVD.
Translated title of the contributionRandomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years
Original languageEnglish
Pages (from-to)852 - 858
Number of pages6
JournalPediatrics
Volume125
Issue number4
DOIs
Publication statusPublished - Mar 2010

Bibliographical note

Other: On line publication

Keywords

  • Thrombolytic Therapy
  • Developmental Disabilities
  • Ventricular Dysfunction
  • Cerebral Hemorrhage
  • Cerebrospinal Fluid Shunts
  • Therapeutic Irrigation
  • Dilatation, Pathologic
  • Drainage
  • Humans
  • Cardiomyopathy, Dilated
  • Infant, Newborn
  • Infant, Premature, Diseases
  • Infant, Premature
  • Treatment Outcome
  • Female
  • Male

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