Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years

Andrew Whitelaw; Sally Jary; Grazyna Kmita; Jolanta Wroblewska; Ewa Musialik-Swietlinska; Marek Mandera; Linda Hunt; Michael Carter; Ian Pople

doi:10.1542/peds.2009-1960

Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years

Andrew Whitelaw, Sally Jary, Grazyna Kmita, Jolanta Wroblewska, Ewa Musialik-Swietlinska, Marek Mandera, Linda Hunt, Michael Carter, Ian Pople

Research output: Contribution to journal › Article (Academic Journal) › peer-review

143 Citations (Scopus)

Abstract

Preterm infants who develop posthemorrhagic ventricular dilatation (PHVD) have a high risk of cognitive and motor disability. No clinical intervention has been proven to reduce neurodevelopmental disability in such infants. We investigated whether drainage, irrigation, and fibrinolytic therapy (DRIFT), which aims to lower pressure, distortion, free iron, and cytokines, reduces death or severe disability in PHVD.

Translated title of the contribution	Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years
Original language	English
Pages (from-to)	852 - 858
Number of pages	6
Journal	Pediatrics
Volume	125
Issue number	4
DOIs	https://doi.org/10.1542/peds.2009-1960
Publication status	Published - Mar 2010

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Keywords

Thrombolytic Therapy
Developmental Disabilities
Ventricular Dysfunction
Cerebral Hemorrhage
Cerebrospinal Fluid Shunts
Therapeutic Irrigation
Dilatation, Pathologic
Drainage
Humans
Cardiomyopathy, Dilated
Infant, Newborn
Infant, Premature, Diseases
Infant, Premature
Treatment Outcome
Female
Male

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Whitelaw, A., Jary, S., Kmita, G., Wroblewska, J., Musialik-Swietlinska, E., Mandera, M., Hunt, L., Carter, M., & Pople, I. (2010). Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years. Pediatrics, 125(4), 852 - 858. https://doi.org/10.1542/peds.2009-1960

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title = "Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years",

abstract = "Preterm infants who develop posthemorrhagic ventricular dilatation (PHVD) have a high risk of cognitive and motor disability. No clinical intervention has been proven to reduce neurodevelopmental disability in such infants. We investigated whether drainage, irrigation, and fibrinolytic therapy (DRIFT), which aims to lower pressure, distortion, free iron, and cytokines, reduces death or severe disability in PHVD.",

keywords = "Thrombolytic Therapy, Developmental Disabilities, Ventricular Dysfunction, Cerebral Hemorrhage, Cerebrospinal Fluid Shunts, Therapeutic Irrigation, Dilatation, Pathologic, Drainage, Humans, Cardiomyopathy, Dilated, Infant, Newborn, Infant, Premature, Diseases, Infant, Premature, Treatment Outcome, Female, Male",

author = "Andrew Whitelaw and Sally Jary and Grazyna Kmita and Jolanta Wroblewska and Ewa Musialik-Swietlinska and Marek Mandera and Linda Hunt and Michael Carter and Ian Pople",

note = "Other: On line publication",

year = "2010",

month = mar,

doi = "10.1542/peds.2009-1960",

language = "English",

volume = "125",

pages = "852 -- 858",

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Whitelaw, A, Jary, S, Kmita, G, Wroblewska, J, Musialik-Swietlinska, E, Mandera, M, Hunt, L, Carter, M & Pople, I 2010, 'Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years', Pediatrics, vol. 125, no. 4, pp. 852 - 858. https://doi.org/10.1542/peds.2009-1960

TY - JOUR

T1 - Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years

AU - Whitelaw, Andrew

AU - Jary, Sally

AU - Kmita, Grazyna

AU - Wroblewska, Jolanta

AU - Musialik-Swietlinska, Ewa

AU - Mandera, Marek

AU - Hunt, Linda

AU - Carter, Michael

AU - Pople, Ian

N1 - Other: On line publication

PY - 2010/3

Y1 - 2010/3

N2 - Preterm infants who develop posthemorrhagic ventricular dilatation (PHVD) have a high risk of cognitive and motor disability. No clinical intervention has been proven to reduce neurodevelopmental disability in such infants. We investigated whether drainage, irrigation, and fibrinolytic therapy (DRIFT), which aims to lower pressure, distortion, free iron, and cytokines, reduces death or severe disability in PHVD.

AB - Preterm infants who develop posthemorrhagic ventricular dilatation (PHVD) have a high risk of cognitive and motor disability. No clinical intervention has been proven to reduce neurodevelopmental disability in such infants. We investigated whether drainage, irrigation, and fibrinolytic therapy (DRIFT), which aims to lower pressure, distortion, free iron, and cytokines, reduces death or severe disability in PHVD.

KW - Thrombolytic Therapy

KW - Developmental Disabilities

KW - Ventricular Dysfunction

KW - Cerebral Hemorrhage

KW - Cerebrospinal Fluid Shunts

KW - Therapeutic Irrigation

KW - Dilatation, Pathologic

KW - Drainage

KW - Humans

KW - Cardiomyopathy, Dilated

KW - Infant, Newborn

KW - Infant, Premature, Diseases

KW - Infant, Premature

KW - Treatment Outcome

KW - Female

KW - Male

U2 - 10.1542/peds.2009-1960

DO - 10.1542/peds.2009-1960

M3 - Article (Academic Journal)

C2 - 20211949

SN - 0031-4005

VL - 125

SP - 852

EP - 858

JO - Pediatrics

JF - Pediatrics

IS - 4

ER -

Randomized Trial of Drainage, Irrigation and Fibrinolytic Therapy for Premature Infants with Post-Hemmorrhagic Ventricular Dilatation : Developmental outcome at 2 years

Abstract

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Keywords

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