TY - JOUR
T1 - Rational and design of EuroCRT
T2 - an international observational study on multi-modality imaging and cardiac resynchronization therapy
AU - Donal, Erwan
AU - Delgado, Victoria
AU - Magne, Julien
AU - Bucciarelli-Ducci, Chiara
AU - Leclercq, Christophe
AU - Cosyns, Bernard
AU - Sitges, Marta
AU - Edvardsen, Thor
AU - Sade, Elif
AU - Stankovic, Ivan
AU - Agricola, Eustachio
AU - Galderisi, Maurizio
AU - Lancellotti, Patrizio
AU - Hernandez, Alfredo
AU - Plein, Sven
AU - Muraru, Denisa
AU - Schwammenthal, Ehud
AU - Hindricks, Gerhard
AU - Popescu, Bogdan A
AU - Habib, Gilbert
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT.Methods: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.
AB - Aims: Assessment of left ventricular (LV) volumes and ejection fraction (LVEF) with cardiac imaging is important in the selection of patients for cardiac resynchronization therapy (CRT). Several observational studies have explored the role of imaging-derived LV dyssynchrony parameters to predict the response to CRT, but have yielded inconsistent results, precluding the inclusion of imaging-derived LV dyssynchrony parameters in current guidelines for selection of patients for CRT.Methods: The EuroCRT is a large European multicentre prospective observational study led by the European Association of Cardiovascular Imaging. We aim to explore if combing the value of cardiac magnetic resonance (CMR) and echocardiography could be beneficial for selecting heart failure patients for CRT in terms of improvement in long-term survival, clinical symptoms, LV function, and volumes. Speckle tracking echocardiography will be used to assess LV dyssynchrony and wasted cardiac work whereas myocardial scar will be assessed with late gadolinium contrast enhanced CMR. All data will be measured in core laboratories. The study will be conducted in European centres with known expertise in both CRT and multimodality cardiac imaging.
KW - Journal Article
U2 - 10.1093/ehjci/jex021
DO - 10.1093/ehjci/jex021
M3 - Article (Academic Journal)
C2 - 28329299
SN - 2047-2404
VL - 18
SP - 1120
EP - 1127
JO - European Heart Journal - Cardiovascular Imaging
JF - European Heart Journal - Cardiovascular Imaging
IS - 10
ER -